Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2712479..2712981 Replicon chromosome
Accession NZ_CP093242
Organism Moellerella wisconsensis strain W65

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MNY66_RS11910 Protein ID WP_241500949.1
Coordinates 2712727..2712981 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MNY66_RS11905 Protein ID WP_241500948.1
Coordinates 2712479..2712730 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY66_RS11885 (MNY66_11885) 2708512..2709777 - 1266 WP_241500944.1 hypothetical protein -
MNY66_RS11890 (MNY66_11890) 2709792..2710238 - 447 WP_241500945.1 hypothetical protein -
MNY66_RS11895 (MNY66_11895) 2710590..2711219 + 630 WP_241500946.1 DNA-binding protein -
MNY66_RS11900 (MNY66_11900) 2711243..2711890 - 648 WP_241500947.1 RES domain-containing protein -
MNY66_RS11905 (MNY66_11905) 2712479..2712730 + 252 WP_241500948.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
MNY66_RS11910 (MNY66_11910) 2712727..2712981 + 255 WP_241500949.1 Txe/YoeB family addiction module toxin Toxin
MNY66_RS11915 (MNY66_11915) 2713029..2713373 - 345 WP_241500950.1 hypothetical protein -
MNY66_RS11920 (MNY66_11920) 2713883..2714329 + 447 WP_241500951.1 DUF3290 domain-containing protein -
MNY66_RS11925 (MNY66_11925) 2714338..2714988 + 651 WP_053907799.1 DUF421 domain-containing protein -
MNY66_RS11930 (MNY66_11930) 2715483..2716442 + 960 WP_241500952.1 Rpn family recombination-promoting nuclease/putative transposase -
MNY66_RS11935 (MNY66_11935) 2716461..2716652 + 192 WP_241500953.1 hypothetical protein -
MNY66_RS11940 (MNY66_11940) 2716671..2716886 + 216 WP_241500954.1 hypothetical protein -
MNY66_RS11945 (MNY66_11945) 2716905..2717096 + 192 WP_241500955.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9926.30 Da        Isoelectric Point: 9.7120

>T237921 WP_241500949.1 NZ_CP093242:2712727-2712981 [Moellerella wisconsensis]
VKLTWSAEAWEDYLYWQETDRKTVKKINELIKNASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSNDSLLIASC
RYHY

Download         Length: 255 bp

>T237921 NZ_LR883006:3647757-3647975 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.89 Da        Isoelectric Point: 5.1367

>AT237921 WP_241500948.1 NZ_CP093242:2712479-2712730 [Moellerella wisconsensis]
MKAVSYSEARQNLSTTMIQTVEDRVPVLITRQNGESCVLMSLDEYNSLEETAYLMRSPKNARRLMDSIESLKDGKGMERE
IIK

Download         Length: 252 bp

>AT237921 NZ_LR883006:3647357-3647731 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References