Detailed information of TA system TA237913

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2789511..2789708
• Replicon: chromosome
• Accession: NZ_CP093239
• Organism: Escherichia marmotae strain W49-2

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: MNY74_RS13465
• Protein ID: WP_201797678.1
• Coordinates: 2789511..2789666 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2789678..2789708 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY74_RS13455	2786030..2787097	-	1068	WP_236942588.1	restriction endonuclease subunit S	-
MNY74_RS13460	2787166..2789349	-	2184	WP_241556616.1	N-6 DNA methylase	-
MNY74_RS13465	2789511..2789666	-	156	WP_201797678.1	Hok/Gef family protein	Toxin
-	2789678..2789708	+	31	-	-	Antitoxin
MNY74_RS13470	2789871..2790281	-	411	WP_241556617.1	antiterminator Q family protein	-
MNY74_RS13475	2790281..2790538	-	258	WP_001064805.1	hypothetical protein	-
MNY74_RS13480	2790535..2791926	-	1392	WP_241556618.1	replicative DNA helicase	-
MNY74_RS13485	2791923..2792801	-	879	WP_241556619.1	ATP-binding protein	-
MNY74_RS13490	2792812..2793636	-	825	WP_241556621.1	helix-turn-helix domain-containing protein	-
MNY74_RS13495	2793633..2793857	-	225	WP_105282055.1	hypothetical protein	-
MNY74_RS13500	2794045..2794707	-	663	WP_241556623.1	ash family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2743630..2802680	59050

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5828.08 Da
• Isoelectric Point: 7.7951

>T237913 WP_201797678.1 NZ_CP093239:c2789666-2789511 [Escherichia marmotae]
MKQQKAMLIALIVICLTVIAMALVMRKDLCEVRIRTGQTEVAVFVDYESRE

Nucleotide

• Length: 156 bp

>T237913 NZ_LR883006:2071306-2071409 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 31 bp

>AT237913 NZ_CP093239:2789678-2789708 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCT

Structures

Antitoxin