Detailed information of TA system TA237912

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-OrzO/Ldr(toxin)
• Location: 2697105..2697328
• Replicon: chromosome
• Accession: NZ_CP093239
• Organism: Escherichia marmotae strain W49-2

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A7H9K3A2
• Locus tag: MNY74_RS12940
• Protein ID: WP_032141347.1
• Coordinates: 2697221..2697328 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	OrzO
Locus tag	-
Coordinates	2697105..2697171 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY74_RS12915	2692384..2693778	-	1395	WP_000087125.1	YchO/YchP family invasin	-
MNY74_RS12920	2693962..2694315	+	354	WP_001169672.1	DsrE/F sulfur relay family protein YchN	-
MNY74_RS12925	2694359..2695054	-	696	WP_001516523.1	glutathione-specific gamma-glutamylcyclotransferase	-
MNY74_RS12930	2695212..2695442	-	231	WP_001146437.1	putative cation transport regulator ChaB	-
MNY74_RS12935	2695711..2696811	+	1101	WP_001516524.1	sodium-potassium/proton antiporter ChaA	-
-	2697105..2697171	-	67	-	-	Antitoxin
MNY74_RS12940	2697221..2697328	+	108	WP_032141347.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
MNY74_RS12945	2697508..2698362	-	855	WP_000811071.1	3-deoxy-8-phosphooctulonate synthase	-
MNY74_RS12950	2698398..2699207	-	810	WP_001257034.1	invasion regulator SirB1	-
MNY74_RS12955	2699211..2699603	-	393	WP_000200357.1	invasion regulator SirB2	-
MNY74_RS12960	2699600..2700433	-	834	WP_105276063.1	peptide chain release factor N(5)-glutamine methyltransferase	-
MNY74_RS12965	2700433..2701515	-	1083	WP_000804714.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3953.71 Da
• Isoelectric Point: 11.4779

>T237912 WP_032141347.1 NZ_CP093239:2697221-2697328 [Escherichia marmotae]
MTLAQFAITFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T237912 NZ_LR883006:c1907666-1907292 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT237912 NZ_CP093239:c2697171-2697105 [Escherichia marmotae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7H9K3A2

Antitoxin