Detailed information of TA system TA237910

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2497633..2497858
• Replicon: chromosome
• Accession: NZ_CP093239
• Organism: Escherichia marmotae strain W49-2

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: MNY74_RS11795
• Protein ID: WP_000813254.1
• Coordinates: 2497633..2497788 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2497800..2497858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY74_RS11760	2492831..2494003	+	1173	WP_000952373.1	IS21-like element IS21 family transposase	-
MNY74_RS11765	2494003..2494800	+	798	WP_000544830.1	IS21-like element IS21 family helper ATPase IstB	-
MNY74_RS11770	2494760..2495347	-	588	WP_241556847.1	DUF1133 family protein	-
MNY74_RS11775	2495344..2495634	-	291	WP_000228021.1	DUF1364 domain-containing protein	-
MNY74_RS11780	2495634..2496233	-	600	WP_001526959.1	DUF1367 family protein	-
MNY74_RS11785	2496741..2497226	-	486	WP_000818163.1	type II toxin-antitoxin system death-on-curing family toxin	-
MNY74_RS11790	2497245..2497424	-	180	WP_000119355.1	hypothetical protein	-
MNY74_RS11795	2497633..2497788	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2497800..2497858	+	59	-	-	Antitoxin
MNY74_RS11800	2498026..2498691	-	666	WP_021554705.1	epoxyqueuosine reductase QueH	-
MNY74_RS11805	2498876..2499292	-	417	WP_001151236.1	DUF977 family protein	-
MNY74_RS11810	2499308..2500021	-	714	WP_001526958.1	DUF1627 domain-containing protein	-
MNY74_RS11815	2500044..2500790	-	747	WP_001526957.1	ATP-binding protein	-
MNY74_RS11820	2500797..2501654	-	858	WP_001526956.1	YdaU family protein	-
MNY74_RS11825	2501667..2502089	-	423	WP_021522079.1	toxin YdaT family protein	-
MNY74_RS11830	2502086..2502328	-	243	WP_001033914.1	helix-turn-helix transcriptional regulator	-
MNY74_RS11835	2502425..2502844	+	420	WP_000410102.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2463044..2511334	48290

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T237910 WP_000813254.1 NZ_CP093239:c2497788-2497633 [Escherichia marmotae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T237910 NZ_LR883006:1890038-1890289 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT237910 NZ_CP093239:2497800-2497858 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin