Detailed information of TA system TA237896

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 811702..811960
• Replicon: chromosome
• Accession: NZ_CP093239
• Organism: Escherichia marmotae strain W49-2

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MNY74_RS03855
• Protein ID: WP_000809168.1
• Coordinates: 811702..811854 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	811903..811960 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY74_RS03830	807027..807593	-	567	WP_000528538.1	acetate uptake transporter	-
MNY74_RS03835	807742..807855	-	114	Protein_749	hypothetical protein	-
MNY74_RS03840	807866..808085	-	220	Protein_750	DUF2541 family protein	-
MNY74_RS03845	808462..810378	+	1917	WP_000516135.1	molecular chaperone DnaK	-
MNY74_RS03850	810467..811597	+	1131	WP_001118463.1	molecular chaperone DnaJ	-
MNY74_RS03855	811702..811854	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	811903..811960	+	58	-	-	Antitoxin
MNY74_RS03860	812438..813604	+	1167	WP_000681378.1	Na+/H+ antiporter NhaA	-
MNY74_RS03865	813664..814569	+	906	WP_000062876.1	transcriptional activator NhaR	-
MNY74_RS03870	814672..814935	-	264	WP_001274018.1	30S ribosomal protein S20	-
MNY74_RS03875	815038..815256	+	219	Protein_757	DUF2575 domain-containing protein	-
MNY74_RS03880	815264..816205	+	942	WP_000767344.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T237896 WP_000809168.1 NZ_CP093239:c811854-811702 [Escherichia marmotae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T237896 NZ_LR882998:105470-105628 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT237896 NZ_CP093239:811903-811960 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin