237831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2911658..2912160 Replicon chromosome
Accession NZ_CP093221
Organism Escherichia coli strain ER2683

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag MNV48_RS13930 Protein ID WP_000767829.1
Coordinates 2911906..2912160 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag MNV48_RS13925 Protein ID WP_001259255.1
Coordinates 2911658..2911909 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNV48_RS13900 (2906836) 2906836..2907903 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
MNV48_RS13905 (2907903) 2907903..2908973 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
MNV48_RS13910 (2908970) 2908970..2910274 - 1305 WP_000009594.1 histidinol dehydrogenase -
MNV48_RS13915 (2910280) 2910280..2911179 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
MNV48_RS13920 (2911325) 2911325..2911375 - 51 WP_001364200.1 his operon leader peptide -
MNV48_RS13925 (2911658) 2911658..2911909 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
MNV48_RS13930 (2911906) 2911906..2912160 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
MNV48_RS13935 (2912243) 2912243..2913067 + 825 WP_000754737.1 SDR family oxidoreductase -
MNV48_RS13940 (2913113) 2913113..2914042 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
MNV48_RS13945 (2914257) 2914257..2914319 + 63 WP_010723108.1 membrane protein YoeI -
MNV48_RS13950 (2914309) 2914309..2915667 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
MNV48_RS13955 (2915846) 2915846..2916904 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
MNV48_RS13960 (2916918) 2916918..2917145 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T237831 WP_000767829.1 NZ_CP093221:2911906-2912160 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T237831 NZ_LR882974:c23416-23258 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT237831 WP_001259255.1 NZ_CP093221:2911658-2911909 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT237831 NZ_LR882974:c23675-23481 [Escherichia coli]
TCACGCGGATTTCCCGTAGCCTGAATGAGCGTATTCTTTTCAGGAAAAGTGAATGTGGCCAGCGCGCAGGGATATGGGCT
ATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACAGTGTTGTGTGGCAGAAGGACAAA
AGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References