Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1837161..1837854 Replicon chromosome
Accession NZ_CP093221
Organism Escherichia coli strain ER2683

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MNV48_RS08915 Protein ID WP_000415584.1
Coordinates 1837161..1837457 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MNV48_RS08920 Protein ID WP_000650107.1
Coordinates 1837459..1837854 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNV48_RS08880 (1832249) 1832249..1832563 - 315 WP_000958598.1 putative quinol monooxygenase -
MNV48_RS08885 (1832594) 1832594..1833175 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MNV48_RS08890 (1833494) 1833494..1833826 + 333 WP_000917684.1 DUF2645 family protein -
MNV48_RS08895 (1833872) 1833872..1835221 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MNV48_RS08900 (1835218) 1835218..1835877 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
MNV48_RS08905 (1836029) 1836029..1836421 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MNV48_RS08910 (1836474) 1836474..1836956 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MNV48_RS08915 (1837161) 1837161..1837457 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MNV48_RS08920 (1837459) 1837459..1837854 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MNV48_RS08925 (1837987) 1837987..1839594 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MNV48_RS08930 (1839732) 1839732..1841990 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T237826 WP_000415584.1 NZ_CP093221:1837161-1837457 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T237826 NZ_LR882973:2655617-2655724 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT237826 WP_000650107.1 NZ_CP093221:1837459-1837854 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT237826 NZ_LR882973:c2655570-2655504 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References