Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 275866..276493 Replicon chromosome
Accession NZ_CP093041
Organism Bartonella krasnovii strain 87B_3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MNL05_RS00995 Protein ID WP_241439665.1
Coordinates 275866..276180 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MNL05_RS01000 Protein ID WP_004861504.1
Coordinates 276197..276493 (+) Length 99 a.a.

Genomic Context

MNL05_RS00995MNL05_RS01000MNL05_RS01020MNL05_RS00970MNL05_RS00975MNL05_RS00980MNL05_RS00985MNL05_RS00990MNL05_RS01005MNL05_RS08760MNL05_RS01025MNL05_RS01030MNL05_RS01035MNL05_RS01040
Location: 275866..276180 (315 bp)
Type: Toxin
Protein ID: WP_241439665.1
Location: 276197..276493 (297 bp)
Type: Antitoxin
Protein ID: WP_004861504.1
Location: 277930..279015 (1086 bp)
Type: Others
Protein ID: WP_241436208.1
Location: 272336..273442 (1107 bp)
Type: Others
Protein ID: WP_241439664.1
Location: 273442..274266 (825 bp)
Type: Others
Protein ID: WP_241436198.1
Location: 274263..274604 (342 bp)
Type: Others
Protein ID: WP_241436199.1
Location: 274601..275290 (690 bp)
Type: Others
Protein ID: WP_241436200.1
Location: 275271..275813 (543 bp)
Type: Others
Protein ID: WP_241436201.1
Location: 276536..276814 (279 bp)
Type: Others
Protein ID: WP_241439666.1
Location: 276811..277549 (739 bp)
Type: Others
Protein ID: Protein_196
Location: 279045..279386 (342 bp)
Type: Others
Protein ID: Protein_198
Location: 279388..280452 (1065 bp)
Type: Others
Protein ID: WP_241439668.1
Location: 280465..280836 (372 bp)
Type: Others
Protein ID: WP_241436210.1
Location: 280833..281171 (339 bp)
Type: Others
Protein ID: WP_241436211.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNL05_RS00970 (MNL05_00970)272336..273442-1107WP_241439664.1phage tail protein-
MNL05_RS00975 (MNL05_00975)273442..274266-825WP_241436198.1baseplate J/gp47 family protein-
MNL05_RS00980 (MNL05_00980)274263..274604-342WP_241436199.1GPW/gp25 family protein-
MNL05_RS00985 (MNL05_00985)274601..275290-690WP_241436200.1phage baseplate assembly protein V-
MNL05_RS00990 (MNL05_00990)275271..275813-543WP_241436201.1hypothetical protein-
MNL05_RS00995 (MNL05_00995)275866..276180+315WP_241439665.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MNL05_RS01000 (MNL05_01000)276197..276493+297WP_004861504.1HigA family addiction module antitoxinAntitoxin
MNL05_RS01005 (MNL05_01005)276536..276814-279WP_241439666.1hypothetical protein-
MNL05_RS08760276811..277549-739Protein_196antA/AntB antirepressor family protein-
MNL05_RS01020 (MNL05_01020)277930..279015+1086WP_241436208.1hypothetical protein-
MNL05_RS01025 (MNL05_01025)279045..279386-342Protein_198hypothetical protein-
MNL05_RS01030 (MNL05_01030)279388..280452-1065WP_241439668.1major capsid protein-
MNL05_RS01035 (MNL05_01035)280465..280836-372WP_241436210.1head decoration protein-
MNL05_RS01040 (MNL05_01040)280833..281171-339WP_241436211.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--250970..30821357243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12194.16 Da        Isoelectric Point: 10.1014

>T237636 WP_241439665.1 NZ_CP093041:275866-276180 [Bartonella krasnovii]
MIRKRMNKGDLVIESFADKRCKDLLEGNPPRGFPPTLVRIAQRKLFMLDKAVELKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Download         Length: 315 bp

>T237636 NZ_LR882498:2869579-2869992 [Mycobacterium tuberculosis variant microti]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11320.99 Da        Isoelectric Point: 5.1546

>AT237636 WP_004861504.1 NZ_CP093041:276197-276493 [Bartonella krasnovii]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSIL
QTEKADEFAKINKFECRV

Download         Length: 297 bp

>AT237636 NZ_LR882498:2870031-2870288 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References