23760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1070746..1071335 Replicon chromosome
Accession NC_012590
Organism Corynebacterium aurimucosum ATCC 700975

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CAURI_RS13585 Protein ID WP_010187287.1
Coordinates 1070746..1071027 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CAURI_RS05115 Protein ID WP_010187286.1
Coordinates 1071036..1071335 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAURI_RS05095 1066349..1067326 - 978 WP_010187290.1 selenide, water dikinase SelD -
CAURI_RS05105 1067478..1068764 + 1287 WP_010187289.1 L-seryl-tRNA(Sec) selenium transferase -
CAURI_RS05110 1068765..1070555 + 1791 WP_012714974.1 selenocysteine-specific translation elongation factor -
CAURI_RS13585 1070746..1071027 + 282 WP_010187287.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CAURI_RS05115 1071036..1071335 + 300 WP_010187286.1 HigA family addiction module antidote protein Antitoxin
CAURI_RS05120 1071784..1072626 - 843 WP_010187285.1 hypothetical protein -
CAURI_RS05125 1072721..1073518 + 798 WP_010187284.1 zinc transporter ZupT -
CAURI_RS05130 1073522..1074442 - 921 WP_010187282.1 DUF808 domain-containing protein -
CAURI_RS05135 1074485..1075021 - 537 WP_010187279.1 DUF402 domain-containing protein -
CAURI_RS05140 1075021..1075740 - 720 WP_010187276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10778.22 Da        Isoelectric Point: 10.7844

>T23760 WP_010187287.1 NC_012590:1070746-1071027 [Corynebacterium aurimucosum ATCC 700975]
MIQSFGNRDTELVWLREASPRIDPRIHKTSNRKLHQLDAAVSLNSLRVPPGNRLEALKGDRKGTFSIRVNQQWRITFRWT
EAGPADVVIEDYH

Download         Length: 282 bp

>T23760 NC_012590:1070746-1071027 [Corynebacterium aurimucosum ATCC 700975]
ATGATCCAGTCTTTCGGTAACCGTGATACCGAGCTTGTCTGGTTACGCGAAGCGTCGCCGCGGATTGATCCGAGAATCCA
TAAAACTTCTAATAGAAAACTCCATCAGCTTGATGCTGCTGTTTCACTGAACTCCTTACGTGTCCCACCGGGTAACCGCC
TCGAGGCTTTGAAAGGTGACCGGAAAGGAACATTCAGTATCCGGGTCAATCAGCAGTGGAGAATCACTTTCCGCTGGACC
GAGGCTGGCCCAGCGGACGTTGTTATCGAGGACTACCACTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11067.62 Da        Isoelectric Point: 5.1215

>AT23760 WP_010187286.1 NC_012590:1071036-1071335 [Corynebacterium aurimucosum ATCC 700975]
MSTKLYPPIHPGEVLNEDFIEAFGITQHKLAVEIGVPPRRINEIVHGKRGITADTALRLGRYFGIEPQYWLNLQSRYELE
VAEDAVADEINGIRPLGAA

Download         Length: 300 bp

>AT23760 NC_012590:1071036-1071335 [Corynebacterium aurimucosum ATCC 700975]
ATGAGTACCAAGCTTTATCCGCCGATTCATCCCGGCGAAGTGCTTAATGAAGATTTCATCGAAGCTTTTGGGATTACCCA
ACACAAACTGGCTGTAGAAATTGGCGTTCCGCCGCGGAGGATTAATGAGATTGTCCACGGCAAGCGTGGAATTACCGCAG
ACACTGCTCTTCGGCTTGGAAGGTACTTCGGCATCGAACCGCAGTATTGGCTCAACCTGCAAAGCCGTTATGAGTTGGAG
GTGGCTGAAGACGCAGTCGCTGATGAAATCAATGGTATTAGGCCCCTCGGGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References