Detailed information of TA system TA237597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 5894636..5895231
• Replicon: chromosome
• Accession: NZ_CP093030
• Organism: Pseudomonas aeruginosa strain H04

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A241XLJ5
• Locus tag: MMZ67_RS28200
• Protein ID: WP_003117425.1
• Coordinates: 5894953..5895231 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MMZ67_RS28195
• Protein ID: WP_003099268.1
• Coordinates: 5894636..5894941 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ67_RS28160 (MMZ67_28165)	5889774..5890622	+	849	WP_003117426.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
MMZ67_RS28170 (MMZ67_28175)	5890789..5891730	+	942	WP_003099281.1	ribose-phosphate pyrophosphokinase	-
MMZ67_RS28175 (MMZ67_28180)	5891847..5892461	+	615	WP_003099279.1	50S ribosomal protein L25/general stress protein Ctc	-
MMZ67_RS28180 (MMZ67_28185)	5892504..5893088	+	585	WP_003099278.1	aminoacyl-tRNA hydrolase	-
MMZ67_RS28185 (MMZ67_28190)	5893129..5894229	+	1101	WP_003099270.1	redox-regulated ATPase YchF	-
MMZ67_RS28195 (MMZ67_28200)	5894636..5894941	-	306	WP_003099268.1	HigA family addiction module antitoxin	Antitoxin
MMZ67_RS28200 (MMZ67_28205)	5894953..5895231	-	279	WP_003117425.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMZ67_RS28205 (MMZ67_28210)	5895284..5895412	-	129	Protein_5580	integrase	-
MMZ67_RS28210 (MMZ67_28215)	5895560..5897788	+	2229	WP_003099265.1	TonB-dependent receptor	-
MMZ67_RS28215 (MMZ67_28220)	5897858..5898505	-	648	WP_003095021.1	carbonate dehydratase	-
MMZ67_RS28220 (MMZ67_28225)	5898567..5899805	-	1239	WP_003113524.1	dipeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-97)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10701.28 Da
• Isoelectric Point: 8.5576

>T237597 WP_003117425.1 NZ_CP093030:c5895231-5894953 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Nucleotide

• Length: 279 bp

>T237597 NZ_LR882498:364708-365010 [Mycobacterium tuberculosis variant microti]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11213.79 Da
• Isoelectric Point: 5.0747

>AT237597 WP_003099268.1 NZ_CP093030:c5894941-5894636 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Nucleotide

• Length: 306 bp

>AT237597 NZ_LR882498:365058-365279 [Mycobacterium tuberculosis variant microti]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Toxin

• AlphaFold DB: A0A241XLJ5