Detailed information of TA system TA237567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5353049..5353644
• Replicon: chromosome
• Accession: NZ_CP093021
• Organism: Pseudomonas aeruginosa strain H09

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V6ALY3
• Locus tag: MMZ72_RS24790
• Protein ID: WP_003113526.1
• Coordinates: 5353366..5353644 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MMZ72_RS24785
• Protein ID: WP_012077435.1
• Coordinates: 5353049..5353354 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ72_RS24750 (MMZ72_24750)	5348188..5349036	+	849	WP_024914553.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
MMZ72_RS24760 (MMZ72_24760)	5349203..5350144	+	942	WP_003099281.1	ribose-phosphate pyrophosphokinase	-
MMZ72_RS24765 (MMZ72_24765)	5350262..5350876	+	615	WP_024914552.1	50S ribosomal protein L25/general stress protein Ctc	-
MMZ72_RS24770 (MMZ72_24770)	5350918..5351502	+	585	WP_003099278.1	aminoacyl-tRNA hydrolase	-
MMZ72_RS24775 (MMZ72_24775)	5351543..5352643	+	1101	WP_003099270.1	redox-regulated ATPase YchF	-
MMZ72_RS24785 (MMZ72_24785)	5353049..5353354	-	306	WP_012077435.1	HigA family addiction module antitoxin	Antitoxin
MMZ72_RS24790 (MMZ72_24790)	5353366..5353644	-	279	WP_003113526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMZ72_RS24795 (MMZ72_24795)	5353697..5354689	-	993	WP_128549834.1	tyrosine-type recombinase/integrase	-
MMZ72_RS24800 (MMZ72_24800)	5354686..5355978	-	1293	WP_128549833.1	hypothetical protein	-
MMZ72_RS24805 (MMZ72_24805)	5356208..5357482	-	1275	WP_241469232.1	zonular occludens toxin family protein	-
MMZ72_RS24810 (MMZ72_24810)	5357486..5357842	-	357	WP_003114150.1	DUF2523 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5353049..5369496	16447

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10646.19 Da
• Isoelectric Point: 7.8937

>T237567 WP_003113526.1 NZ_CP093021:c5353644-5353366 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Nucleotide

• Length: 279 bp

>T237567 NZ_LR882497:2215792-2216169 [Mycobacterium tuberculosis variant microti]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11184.65 Da
• Isoelectric Point: 4.6081

>AT237567 WP_012077435.1 NZ_CP093021:c5353354-5353049 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLTELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Nucleotide

• Length: 306 bp

>AT237567 NZ_LR882497:2216211-2216660 [Mycobacterium tuberculosis variant microti]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Structures

Toxin

• AlphaFold DB: V6ALY3