Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
Location | 2724977..2725572 | Replicon | chromosome |
Accession | NZ_CP093016 | ||
Organism | Pseudomonas aeruginosa strain H15 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | MMZ75_RS12635 | Protein ID | WP_071538299.1 |
Coordinates | 2724977..2725255 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | MMZ75_RS12640 | Protein ID | WP_003123432.1 |
Coordinates | 2725267..2725572 (+) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MMZ75_RS12615 (MMZ75_12610) | 2720403..2721641 | + | 1239 | WP_003123433.1 | C69 family dipeptidase | - |
MMZ75_RS12620 (MMZ75_12615) | 2721703..2722350 | + | 648 | WP_003095021.1 | carbonate dehydratase | - |
MMZ75_RS12625 (MMZ75_12620) | 2722420..2724648 | - | 2229 | WP_003113525.1 | TonB-dependent receptor | - |
MMZ75_RS12630 (MMZ75_12625) | 2724796..2724924 | + | 129 | Protein_2494 | integrase | - |
MMZ75_RS12635 (MMZ75_12630) | 2724977..2725255 | + | 279 | WP_071538299.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MMZ75_RS12640 (MMZ75_12635) | 2725267..2725572 | + | 306 | WP_003123432.1 | HigA family addiction module antitoxin | Antitoxin |
MMZ75_RS12650 (MMZ75_12645) | 2725978..2727078 | - | 1101 | WP_003099270.1 | redox-regulated ATPase YchF | - |
MMZ75_RS12655 (MMZ75_12650) | 2727119..2727703 | - | 585 | WP_003123431.1 | aminoacyl-tRNA hydrolase | - |
MMZ75_RS12660 (MMZ75_12655) | 2727745..2728359 | - | 615 | WP_003099279.1 | 50S ribosomal protein L25/general stress protein Ctc | - |
MMZ75_RS12665 (MMZ75_12660) | 2728476..2729417 | - | 942 | WP_003099281.1 | ribose-phosphate pyrophosphokinase | - |
MMZ75_RS12675 (MMZ75_12670) | 2729584..2730432 | - | 849 | WP_003123430.1 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10616.17 Da Isoelectric Point: 7.8937
>T237547 WP_071538299.1 NZ_CP093016:2724977-2725255 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T237547 NZ_LR882497:718151-718546 [Mycobacterium tuberculosis variant microti]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11204.78 Da Isoelectric Point: 4.7769
>AT237547 WP_003123432.1 NZ_CP093016:2725267-2725572 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG
Download Length: 306 bp
>AT237547 NZ_LR882497:717897-718151 [Mycobacterium tuberculosis variant microti]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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