Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2724977..2725572 Replicon chromosome
Accession NZ_CP093016
Organism Pseudomonas aeruginosa strain H15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MMZ75_RS12635 Protein ID WP_071538299.1
Coordinates 2724977..2725255 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MMZ75_RS12640 Protein ID WP_003123432.1
Coordinates 2725267..2725572 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ75_RS12615 (MMZ75_12610) 2720403..2721641 + 1239 WP_003123433.1 C69 family dipeptidase -
MMZ75_RS12620 (MMZ75_12615) 2721703..2722350 + 648 WP_003095021.1 carbonate dehydratase -
MMZ75_RS12625 (MMZ75_12620) 2722420..2724648 - 2229 WP_003113525.1 TonB-dependent receptor -
MMZ75_RS12630 (MMZ75_12625) 2724796..2724924 + 129 Protein_2494 integrase -
MMZ75_RS12635 (MMZ75_12630) 2724977..2725255 + 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMZ75_RS12640 (MMZ75_12635) 2725267..2725572 + 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
MMZ75_RS12650 (MMZ75_12645) 2725978..2727078 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
MMZ75_RS12655 (MMZ75_12650) 2727119..2727703 - 585 WP_003123431.1 aminoacyl-tRNA hydrolase -
MMZ75_RS12660 (MMZ75_12655) 2727745..2728359 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
MMZ75_RS12665 (MMZ75_12660) 2728476..2729417 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
MMZ75_RS12675 (MMZ75_12670) 2729584..2730432 - 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T237547 WP_071538299.1 NZ_CP093016:2724977-2725255 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T237547 NZ_LR882497:718151-718546 [Mycobacterium tuberculosis variant microti]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT237547 WP_003123432.1 NZ_CP093016:2725267-2725572 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT237547 NZ_LR882497:717897-718151 [Mycobacterium tuberculosis variant microti]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References