237545

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5642445..5643040 Replicon chromosome
Accession NZ_CP093015
Organism Pseudomonas aeruginosa strain H16

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag MMZ76_RS26350 Protein ID WP_003113526.1
Coordinates 5642762..5643040 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag MMZ76_RS26345 Protein ID WP_003111575.1
Coordinates 5642445..5642750 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ76_RS26310 (MMZ76_26315) 5637585..5638433 + 849 WP_023122792.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
MMZ76_RS26320 (MMZ76_26325) 5638600..5639541 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
MMZ76_RS26325 (MMZ76_26330) 5639658..5640272 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
MMZ76_RS26330 (MMZ76_26335) 5640314..5640898 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
MMZ76_RS26335 (MMZ76_26340) 5640939..5642039 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
MMZ76_RS26345 (MMZ76_26350) 5642445..5642750 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
MMZ76_RS26350 (MMZ76_26355) 5642762..5643040 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMZ76_RS26355 (MMZ76_26360) 5643093..5643221 - 129 Protein_5210 integrase -
MMZ76_RS26360 (MMZ76_26365) 5643369..5645597 + 2229 WP_094954061.1 TonB-dependent receptor -
MMZ76_RS26365 (MMZ76_26370) 5645668..5646315 - 648 WP_003095021.1 carbonate dehydratase -
MMZ76_RS26370 (MMZ76_26375) 5646377..5647615 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T237545 WP_003113526.1 NZ_CP093015:c5643040-5642762 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T237545 NZ_LR882497:704957-705358 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT237545 WP_003111575.1 NZ_CP093015:c5642750-5642445 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT237545 NZ_LR882497:704715-704960 [Mycobacterium tuberculosis variant microti]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References