Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 4582565..4583883 | Replicon | chromosome |
| Accession | NZ_CP093011 | ||
| Organism | Escherichia coli strain 131 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | F4T5A3 |
| Locus tag | LJF86_RS22150 | Protein ID | WP_001262467.1 |
| Coordinates | 4582565..4583572 (-) | Length | 336 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | F4T5A4 |
| Locus tag | LJF86_RS22155 | Protein ID | WP_001312177.1 |
| Coordinates | 4583572..4583883 (-) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF86_RS22120 (4577775) | 4577775..4577966 | + | 192 | WP_000988308.1 | cellulose biosynthesis protein BcsF | - |
| LJF86_RS22125 (4577963) | 4577963..4579642 | + | 1680 | Protein_4349 | cellulose biosynthesis protein BcsG | - |
| LJF86_RS22130 (4579728) | 4579728..4579835 | - | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| LJF86_RS22135 (4580211) | 4580211..4580318 | - | 108 | WP_000170748.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| LJF86_RS22140 (4580694) | 4580694..4580801 | - | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| LJF86_RS22145 (4581277) | 4581277..4582548 | + | 1272 | WP_001545666.1 | amino acid permease | - |
| LJF86_RS22150 (4582565) | 4582565..4583572 | - | 1008 | WP_001262467.1 | HipA domain-containing protein | Toxin |
| LJF86_RS22155 (4583572) | 4583572..4583883 | - | 312 | WP_001312177.1 | HipA N-terminal domain-containing protein | Antitoxin |
| LJF86_RS22160 (4583868) | 4583868..4584191 | - | 324 | WP_000563102.1 | helix-turn-helix transcriptional regulator | - |
| LJF86_RS22165 (4584416) | 4584416..4585429 | - | 1014 | WP_000103572.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| LJF86_RS22170 (4585426) | 4585426..4586409 | - | 984 | WP_001196477.1 | dipeptide ABC transporter ATP-binding protein | - |
| LJF86_RS22175 (4586420) | 4586420..4587322 | - | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
| LJF86_RS22180 (4587332) | 4587332..4588351 | - | 1020 | WP_000938855.1 | dipeptide ABC transporter permease DppB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 336 a.a. Molecular weight: 38320.60 Da Isoelectric Point: 5.5965
>T237521 WP_001262467.1 NZ_CP093011:c4583572-4582565 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
Download Length: 1008 bp
>T237521 NZ_LR882496:2860904-2861281 [Mycobacterium tuberculosis variant microti]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11821.47 Da Isoelectric Point: 6.0609
>AT237521 WP_001312177.1 NZ_CP093011:c4583883-4583572 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
Download Length: 312 bp
>AT237521 NZ_LR882496:2860650-2860907 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3K2ZTB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L3HKE2 |