Detailed information of TA system TA237519

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4580694..4580916
• Replicon: chromosome
• Accession: NZ_CP093011
• Organism: Escherichia coli strain 131

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: LJF86_RS22140
• Protein ID: WP_001295224.1
• Coordinates: 4580694..4580801 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4580850..4580916 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF86_RS22110	4575746..4575934	-	189	WP_001063314.1	cellulose biosynthesis protein BcsR	-
LJF86_RS22115	4576207..4577778	+	1572	WP_001204941.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LJF86_RS22120	4577775..4577966	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LJF86_RS22125	4577963..4579642	+	1680	Protein_4349	cellulose biosynthesis protein BcsG	-
LJF86_RS22130	4579728..4579835	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
LJF86_RS22135	4580211..4580318	-	108	WP_000170748.1	type I toxin-antitoxin system toxin Ldr family protein	-
LJF86_RS22140	4580694..4580801	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4580850..4580916	+	67	-	-	Antitoxin
LJF86_RS22145	4581277..4582548	+	1272	WP_001545666.1	amino acid permease	-
LJF86_RS22150	4582565..4583572	-	1008	WP_001262467.1	HipA domain-containing protein	-
LJF86_RS22155	4583572..4583883	-	312	WP_001312177.1	HipA N-terminal domain-containing protein	-
LJF86_RS22160	4583868..4584191	-	324	WP_000563102.1	helix-turn-helix transcriptional regulator	-
LJF86_RS22165	4584416..4585429	-	1014	WP_000103572.1	dipeptide ABC transporter ATP-binding subunit DppF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T237519 WP_001295224.1 NZ_CP093011:c4580801-4580694 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T237519 NZ_LR882496:c2846729-2846310 [Mycobacterium tuberculosis variant microti]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT237519 NZ_CP093011:4580850-4580916 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin