Detailed information of TA system TA237428

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4902065..4902618
• Replicon: chromosome
• Accession: NZ_CP092971
• Organism: Xanthomonas oryzae strain NJ01

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: MML47_RS22380
• Protein ID: WP_241443399.1
• Coordinates: 4902373..4902618 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MML47_RS22375
• Protein ID: WP_053503948.1
• Coordinates: 4902065..4902355 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MML47_RS22355 (MML47_22355)	4898939..4899271	+	333	WP_003482333.1	hypothetical protein	-
MML47_RS22360 (MML47_22360)	4899431..4899618	+	188	Protein_4253	hypothetical protein	-
MML47_RS22365 (MML47_22365)	4899721..4901115	-	1395	WP_053503949.1	type III secretion system effector XopQ	-
MML47_RS22370 (MML47_22370)	4901390..4901755	-	366	WP_241442428.1	hypothetical protein	-
MML47_RS22375 (MML47_22375)	4902065..4902355	-	291	WP_053503948.1	HigA family addiction module antitoxin	Antitoxin
MML47_RS22380 (MML47_22380)	4902373..4902618	-	246	WP_241443399.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MML47_RS22385 (MML47_22385)	4902749..4905010	-	2262	WP_241442430.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-81)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9657.17 Da
• Isoelectric Point: 10.2114

>T237428 WP_241443399.1 NZ_CP092971:c4902618-4902373 [Xanthomonas oryzae]
IRLGERSRRLPAESQMVARRKLRMLDAAAHPEDLRIPPANRLEALKGQWRGQCSIRINDQWRICFRWMEGDVFQVEIVDY
H

Nucleotide

• Length: 246 bp

>T237428 NZ_LR882054:86988-87368 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGACGGCCTGCCGGGAATGTC
TGATCCGGGTAAGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10345.95 Da
• Isoelectric Point: 6.4654

>AT237428 WP_053503948.1 NZ_CP092971:c4902355-4902065 [Xanthomonas oryzae]
MTVLANIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT237428 NZ_LR882054:86767-86988 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA