Detailed information of TA system TA237407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4843051..4843653
• Replicon: chromosome
• Accession: NZ_CP092911
• Organism: Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A603E470
• Locus tag: MLD58_RS23725
• Protein ID: WP_023138876.1
• Coordinates: 4843051..4843362 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MLD58_RS23730
• Protein ID: WP_000362050.1
• Coordinates: 4843363..4843653 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLD58_RS23700 (4839008)	4839008..4839607	+	600	WP_000965695.1	glucose-1-phosphatase	-
MLD58_RS23705 (4839601)	4839601..4840473	+	873	WP_000921423.1	virulence factor BrkB family protein	-
MLD58_RS23710 (4840470)	4840470..4840907	+	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
MLD58_RS23715 (4840952)	4840952..4841893	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MLD58_RS23720 (4841919)	4841919..4842833	-	915	WP_023138875.1	alpha/beta hydrolase	-
MLD58_RS23725 (4843051)	4843051..4843362	+	312	WP_023138876.1	hypothetical protein	Toxin
MLD58_RS23730 (4843363)	4843363..4843653	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
MLD58_RS23735 (4843700)	4843700..4844629	-	930	WP_023138877.1	formate dehydrogenase accessory protein FdhE	-
MLD58_RS23740 (4844626)	4844626..4845261	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MLD58_RS23745 (4845258)	4845258..4846160	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12356.30 Da
• Isoelectric Point: 9.4460

>T237407 WP_023138876.1 NZ_CP092911:4843051-4843362 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T237407 NZ_LR882052:647887-648201 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT237407 WP_000362050.1 NZ_CP092911:4843363-4843653 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT237407 NZ_LR882052:648198-648614 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A603E470