Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2507658..2508385 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name higB Uniprot ID A0A8E5IJ81
Locus tag MLD58_RS12265 Protein ID WP_000558157.1
Coordinates 2507658..2507969 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MLD58_RS12270 Protein ID WP_000561389.1
Coordinates 2507966..2508385 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS12225 (2502702) 2502702..2503097 + 396 WP_000422887.1 DUF1398 domain-containing protein -
MLD58_RS12230 (2503426) 2503426..2503902 + 477 WP_023138823.1 hypothetical protein -
MLD58_RS12235 (2504054) 2504054..2504206 + 153 WP_157794946.1 hypothetical protein -
MLD58_RS12240 (2504318) 2504318..2504776 - 459 WP_001195655.1 hypothetical protein -
MLD58_RS12245 (2505102) 2505102..2506249 + 1148 WP_112324583.1 IS3 family transposase -
MLD58_RS12250 (2506280) 2506280..2506837 - 558 WP_000179886.1 hypothetical protein -
MLD58_RS12255 (2506941) 2506941..2507150 - 210 WP_023137948.1 hypothetical protein -
MLD58_RS12260 (2507180) 2507180..2507479 - 300 WP_000775225.1 hypothetical protein -
MLD58_RS12265 (2507658) 2507658..2507969 + 312 WP_000558157.1 type II toxin-antitoxin system HigB family toxin Toxin
MLD58_RS12270 (2507966) 2507966..2508385 + 420 WP_000561389.1 helix-turn-helix domain-containing protein Antitoxin
MLD58_RS12275 (2508638) 2508638..2509290 + 653 Protein_2401 glycosyltransferase -
MLD58_RS12280 (2509526) 2509526..2509945 - 420 WP_023137951.1 GNAT family N-acetyltransferase -
MLD58_RS12285 (2510315) 2510315..2510584 + 270 WP_077908593.1 hypothetical protein -
MLD58_RS12290 (2510750) 2510750..2510890 + 141 WP_001576018.1 hypothetical protein -
MLD58_RS12295 (2511036) 2511036..2511577 - 542 Protein_2405 transposase -
MLD58_RS12300 (2511597) 2511597..2511689 - 93 WP_231923105.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2505102..2511374 6272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12425.26 Da        Isoelectric Point: 10.1376

>T237394 WP_000558157.1 NZ_CP092911:2507658-2507969 [Salmonella enterica subsp. enterica]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T237394 NZ_LR882050:3295407-3295514 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15301.49 Da        Isoelectric Point: 4.6286

>AT237394 WP_000561389.1 NZ_CP092911:2507966-2508385 [Salmonella enterica subsp. enterica]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT237394 NZ_LR882050:c3295350-3295295 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References