Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2717788..2718121 Replicon chromosome
Accession NZ_CP092907
Organism Enterococcus faecalis strain LJX 0909

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag MK744_RS13090 Protein ID WP_002392696.1
Coordinates 2717788..2717931 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2717905..2718121 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK744_RS13075 (2714007) 2714007..2714645 - 639 WP_002375448.1 lytic polysaccharide monooxygenase -
MK744_RS13080 (2715330) 2715330..2716946 + 1617 WP_085444189.1 phosphatase PAP2/LCP family protein -
MK744_RS13085 (2717161) 2717161..2717358 + 198 WP_002358966.1 type I toxin-antitoxin system toxin PepG1 -
- (2717291) 2717291..2717477 - 187 NuclAT_5 - -
- (2717508) 2717508..2717676 - 169 NuclAT_10 - -
- (2717530) 2717530..2717676 - 147 NuclAT_8 - -
MK744_RS13090 (2717788) 2717788..2717931 + 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2717864) 2717864..2718119 - 256 NuclAT_4 - -
- (2718071) 2718071..2718120 + 50 NuclAT_13 - -
- (2717905) 2717905..2718121 - 217 NuclAT_9 - Antitoxin
MK744_RS13095 (2718121) 2718121..2721030 - 2910 WP_241408261.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T237386 WP_002392696.1 NZ_CP092907:2717788-2717931 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T237386 NZ_LR882050:1062411-1062518 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 217 bp

>AT237386 NZ_CP092907:c2718121-2717905 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCAATTGTATTATTT
AAAAATAACCGTACTGGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References