Detailed information of TA system TA237375

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2717161..2717477
• Replicon: chromosome
• Accession: NZ_CP092907
• Organism: Enterococcus faecalis strain LJX 0909

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: C7CYQ7
• Locus tag: MK744_RS13085
• Protein ID: WP_002358966.1
• Coordinates: 2717161..2717358 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2717291..2717477 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MK744_RS13065 (2712397)	2712397..2712612	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
MK744_RS13070 (2712751)	2712751..2713743	+	993	WP_241408260.1	biotin--[acetyl-CoA-carboxylase] ligase	-
MK744_RS13075 (2714007)	2714007..2714645	-	639	WP_002375448.1	lytic polysaccharide monooxygenase	-
MK744_RS13080 (2715330)	2715330..2716946	+	1617	WP_085444189.1	phosphatase PAP2/LCP family protein	-
MK744_RS13085 (2717161)	2717161..2717358	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2717291)	2717291..2717477	-	187	NuclAT_5	-	Antitoxin
- (2717508)	2717508..2717676	-	169	NuclAT_10	-	-
- (2717530)	2717530..2717676	-	147	NuclAT_8	-	-
MK744_RS13090 (2717788)	2717788..2717931	+	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	-
- (2717864)	2717864..2718119	-	256	NuclAT_4	-	-
- (2718071)	2718071..2718120	+	50	NuclAT_13	-	-
- (2717905)	2717905..2718121	-	217	NuclAT_9	-	-
MK744_RS13095 (2718121)	2718121..2721030	-	2910	WP_241408261.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (32-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7571.21 Da
• Isoelectric Point: 10.8134

>T237375 WP_002358966.1 NZ_CP092907:2717161-2717358 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 198 bp

>T237375 NZ_LR881940:c4192460-4192287 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 187 bp

>AT237375 NZ_CP092907:c2717477-2717291 [Enterococcus faecalis]
TGTGCTATAATGAAAAGGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTTT
TAGTTACAAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: C7CYQ7

Antitoxin