Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2634702..2635208 Replicon chromosome
Accession NZ_CP092907
Organism Enterococcus faecalis strain LJX 0909

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag MK744_RS12705 Protein ID WP_002392696.1
Coordinates 2634702..2634845 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2635010..2635208 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK744_RS12690 (2629951) 2629951..2630664 - 714 WP_002354877.1 trehalose operon repressor -
MK744_RS12695 (2630925) 2630925..2633669 + 2745 WP_142957073.1 glycosyl hydrolase family 65 protein -
MK744_RS12700 (2633684) 2633684..2634334 + 651 WP_002419627.1 beta-phosphoglucomutase -
- (2634403) 2634403..2634542 + 140 NuclAT_12 - -
- (2634584) 2634584..2634728 + 145 NuclAT_11 - -
- (2634584) 2634584..2634769 + 186 NuclAT_7 - -
MK744_RS12705 (2634702) 2634702..2634845 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2635010) 2635010..2635208 + 199 NuclAT_6 - Antitoxin
MK744_RS12710 (2635141) 2635141..2635284 - 144 WP_202497224.1 type I toxin-antitoxin system toxin PepG1 -
MK744_RS12715 (2635516) 2635516..2636487 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
MK744_RS12720 (2636662) 2636662..2637099 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
MK744_RS12725 (2637232) 2637232..2637786 - 555 WP_002354869.1 Maf family protein -
MK744_RS12730 (2637811) 2637811..2639943 - 2133 WP_142957075.1 DNA mismatch repair endonuclease MutL -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-47)


Sequences


Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T237369 WP_002392696.1 NZ_CP092907:c2634845-2634702 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T237369 NZ_LR881940:3482065-3482283 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 199 bp

>AT237369 NZ_CP092907:2635010-2635208 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGCTAAACATACCAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S4BYM2


Antitoxin

Download structure file

References