Detailed information of TA system TA237369

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2634702..2635208
• Replicon: chromosome
• Accession: NZ_CP092907
• Organism: Enterococcus faecalis strain LJX 0909

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: MK744_RS12705
• Protein ID: WP_002392696.1
• Coordinates: 2634702..2634845 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2635010..2635208 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MK744_RS12690 (2629951)	2629951..2630664	-	714	WP_002354877.1	trehalose operon repressor	-
MK744_RS12695 (2630925)	2630925..2633669	+	2745	WP_142957073.1	glycosyl hydrolase family 65 protein	-
MK744_RS12700 (2633684)	2633684..2634334	+	651	WP_002419627.1	beta-phosphoglucomutase	-
- (2634403)	2634403..2634542	+	140	NuclAT_12	-	-
- (2634584)	2634584..2634728	+	145	NuclAT_11	-	-
- (2634584)	2634584..2634769	+	186	NuclAT_7	-	-
MK744_RS12705 (2634702)	2634702..2634845	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2635010)	2635010..2635208	+	199	NuclAT_6	-	Antitoxin
MK744_RS12710 (2635141)	2635141..2635284	-	144	WP_202497224.1	type I toxin-antitoxin system toxin PepG1	-
MK744_RS12715 (2635516)	2635516..2636487	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
MK744_RS12720 (2636662)	2636662..2637099	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
MK744_RS12725 (2637232)	2637232..2637786	-	555	WP_002354869.1	Maf family protein	-
MK744_RS12730 (2637811)	2637811..2639943	-	2133	WP_142957075.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T237369 WP_002392696.1 NZ_CP092907:c2634845-2634702 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T237369 NZ_LR881940:3482065-3482283 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT237369 NZ_CP092907:2635010-2635208 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGCTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin