Detailed information of TA system TA237363

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2568240..2568463
• Replicon: chromosome
• Accession: NZ_CP092907
• Organism: Enterococcus faecalis strain LJX 0909

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MK744_RS12400
• Protein ID: WP_162780856.1
• Coordinates: 2568362..2568463 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2568240..2568425 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MK744_RS12375 (2563857)	2563857..2564810	-	954	WP_010823270.1	siderophore ABC transporter substrate-binding protein	-
MK744_RS12380 (2564849)	2564849..2565604	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
MK744_RS12385 (2565601)	2565601..2566566	-	966	WP_142957064.1	iron chelate uptake ABC transporter family permease subunit	-
MK744_RS12390 (2566563)	2566563..2567510	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
MK744_RS12395 (2567695)	2567695..2568147	+	453	WP_002359057.1	YueI family protein	-
- (2568203)	2568203..2568408	+	206	NuclAT_15	-	-
- (2568240)	2568240..2568425	+	186	NuclAT_14	-	Antitoxin
MK744_RS12400 (2568362)	2568362..2568463	-	102	WP_162780856.1	putative holin-like toxin	Toxin
MK744_RS12405 (2568654)	2568654..2570924	-	2271	WP_142957065.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
MK744_RS12410 (2571095)	2571095..2571595	+	501	WP_142957066.1	cysteine hydrolase family protein	-
MK744_RS12415 (2571941)	2571941..2572837	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T237363 WP_162780856.1 NZ_CP092907:c2568463-2568362 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T237363 NZ_LR881940:2012743-2012846 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 186 bp

>AT237363 NZ_CP092907:2568240-2568425 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGCTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin