Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2568240..2568463 Replicon chromosome
Accession NZ_CP092907
Organism Enterococcus faecalis strain LJX 0909

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag MK744_RS12400 Protein ID WP_162780856.1
Coordinates 2568362..2568463 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2568240..2568425 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK744_RS12375 (2563857) 2563857..2564810 - 954 WP_010823270.1 siderophore ABC transporter substrate-binding protein -
MK744_RS12380 (2564849) 2564849..2565604 - 756 WP_002354962.1 ATP-binding cassette domain-containing protein -
MK744_RS12385 (2565601) 2565601..2566566 - 966 WP_142957064.1 iron chelate uptake ABC transporter family permease subunit -
MK744_RS12390 (2566563) 2566563..2567510 - 948 WP_002394759.1 iron chelate uptake ABC transporter family permease subunit -
MK744_RS12395 (2567695) 2567695..2568147 + 453 WP_002359057.1 YueI family protein -
- (2568203) 2568203..2568408 + 206 NuclAT_15 - -
- (2568240) 2568240..2568425 + 186 NuclAT_14 - Antitoxin
MK744_RS12400 (2568362) 2568362..2568463 - 102 WP_162780856.1 putative holin-like toxin Toxin
MK744_RS12405 (2568654) 2568654..2570924 - 2271 WP_142957065.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
MK744_RS12410 (2571095) 2571095..2571595 + 501 WP_142957066.1 cysteine hydrolase family protein -
MK744_RS12415 (2571941) 2571941..2572837 + 897 WP_002368434.1 YitT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-33)


Sequences

Toxin        


Download         Length: 34 a.a.        Molecular weight: 3624.40 Da        Isoelectric Point: 6.0656

>T237363 WP_162780856.1 NZ_CP092907:c2568463-2568362 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Download         Length: 102 bp

>T237363 NZ_LR881940:2012743-2012846 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 186 bp

>AT237363 NZ_CP092907:2568240-2568425 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGCTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References