Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4870059..4870813 | Replicon | chromosome |
| Accession | NZ_CP092861 | ||
| Organism | Salmonella enterica strain P164045 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A3Z1E8E0 |
| Locus tag | MLB75_RS24270 | Protein ID | WP_000558163.1 |
| Coordinates | 4870059..4870370 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MLB75_RS24275 | Protein ID | WP_001259012.1 |
| Coordinates | 4870367..4870813 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLB75_RS24240 (4865725) | 4865725..4866627 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| MLB75_RS24245 (4866624) | 4866624..4867259 | + | 636 | WP_241065957.1 | formate dehydrogenase cytochrome b556 subunit | - |
| MLB75_RS24250 (4867256) | 4867256..4868185 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| MLB75_RS24255 (4868223) | 4868223..4868597 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| MLB75_RS24260 (4868597) | 4868597..4868839 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| MLB75_RS24265 (4869044) | 4869044..4869973 | + | 930 | WP_001162860.1 | alpha/beta hydrolase | - |
| MLB75_RS24270 (4870059) | 4870059..4870370 | + | 312 | WP_000558163.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MLB75_RS24275 (4870367) | 4870367..4870813 | + | 447 | WP_001259012.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| MLB75_RS24280 (4870828) | 4870828..4871769 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| MLB75_RS24285 (4871814) | 4871814..4872251 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| MLB75_RS24290 (4872248) | 4872248..4873120 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| MLB75_RS24295 (4873114) | 4873114..4873713 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| MLB75_RS24300 (4873904) | 4873904..4874707 | - | 804 | WP_098097576.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| MLB75_RS24305 (4874741) | 4874741..4875637 | - | 897 | WP_064047151.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12406.36 Da Isoelectric Point: 9.5921
>T237317 WP_000558163.1 NZ_CP092861:4870059-4870370 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T237317 NZ_LR881935:c261029-260571 [Citrobacter freundii]
GTGATCCTGTATCGGATGACCAAGACCCGCTATATTACGACTGCATGGTCGGGATTAGGTGCGAAAGAAGCGGGAGGCCG
CTGGAACAGTGTCGGCACAGCACTTGTCTATCTGTCCGAGACGGCCTCTCTGACCATGCTGGAGACGCTGGTGCATATCA
ATGCCCCGCAGCTTCTGGACGCTTACACGCTGCTGAGCATTGATGTCCCGGATGACCAGATCCAGGCCTTTGACTTGAAC
CTGCTGCCGCCGGGCTGGGCAAGTGAAGATGCGCCCGCAGAACTTGCCCTGTATGGCGATAACTGGGCTGAAAGTGGCTC
TTCTGTTGCCCTGCGTATTCCCAGTGCATTATCTCCGGTGGAGTTTAACTACCTTTTAAATCCGGCTCATCCGGCGATTT
TTGATCTGATGAAAACCGTCCAGAAAATTCCTTACCAGTACGACACACGGCTGAAATAG
GTGATCCTGTATCGGATGACCAAGACCCGCTATATTACGACTGCATGGTCGGGATTAGGTGCGAAAGAAGCGGGAGGCCG
CTGGAACAGTGTCGGCACAGCACTTGTCTATCTGTCCGAGACGGCCTCTCTGACCATGCTGGAGACGCTGGTGCATATCA
ATGCCCCGCAGCTTCTGGACGCTTACACGCTGCTGAGCATTGATGTCCCGGATGACCAGATCCAGGCCTTTGACTTGAAC
CTGCTGCCGCCGGGCTGGGCAAGTGAAGATGCGCCCGCAGAACTTGCCCTGTATGGCGATAACTGGGCTGAAAGTGGCTC
TTCTGTTGCCCTGCGTATTCCCAGTGCATTATCTCCGGTGGAGTTTAACTACCTTTTAAATCCGGCTCATCCGGCGATTT
TTGATCTGATGAAAACCGTCCAGAAAATTCCTTACCAGTACGACACACGGCTGAAATAG
Antitoxin
Download Length: 149 a.a. Molecular weight: 16750.08 Da Isoelectric Point: 6.6451
>AT237317 WP_001259012.1 NZ_CP092861:4870367-4870813 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT237317 NZ_LR881935:c261472-261026 [Citrobacter freundii]
ATGACTATGAAAGTTTTTTCTCCAGATTTATCCAAAATGAACCCGCACGGCTTATGGCAGGTGGTGGGTCTGGATAATGA
CGGCATTGCGCTGATGGACAAAATTAGCCACGGACTGGAAGGTAAAGTCGCTCATTCCATTTCTGAATGGGCGAACATCA
CGCCGTCGGAACTGCGCAAAATGTCCGGCATTCCGAACACCACCTTCAATCGCAGCGTAAAAGCCCGTTTCACTGCGGAT
CAGAGCGAACGTCTGGTGCGTATTATTCGCGTCATTGAACGGGCTGTAGAGCTGTTCGAAGGCGACAAAGAGGCAGCACA
GAAATGGATGAACGAGCCAAACCGTGGCTTGAGCTGGAAGACTCCGGCAGATGTTGTCTCTTCGGAAACCGGCGCACTCG
AAGTGATGCGCCTGATCACCCGTATTGAACACGGAGTCTATTCGTGA
ATGACTATGAAAGTTTTTTCTCCAGATTTATCCAAAATGAACCCGCACGGCTTATGGCAGGTGGTGGGTCTGGATAATGA
CGGCATTGCGCTGATGGACAAAATTAGCCACGGACTGGAAGGTAAAGTCGCTCATTCCATTTCTGAATGGGCGAACATCA
CGCCGTCGGAACTGCGCAAAATGTCCGGCATTCCGAACACCACCTTCAATCGCAGCGTAAAAGCCCGTTTCACTGCGGAT
CAGAGCGAACGTCTGGTGCGTATTATTCGCGTCATTGAACGGGCTGTAGAGCTGTTCGAAGGCGACAAAGAGGCAGCACA
GAAATGGATGAACGAGCCAAACCGTGGCTTGAGCTGGAAGACTCCGGCAGATGTTGTCTCTTCGGAAACCGGCGCACTCG
AAGTGATGCGCCTGATCACCCGTATTGAACACGGAGTCTATTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|