Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 274864..275383 Replicon chromosome
Accession NZ_CP092857
Organism Staphylococcus capitis strain LR 95

Toxin (Protein)


Gene name yoeB Uniprot ID A0A507SVT5
Locus tag MMG96_RS01185 Protein ID WP_002436254.1
Coordinates 274864..275133 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J4EAU6
Locus tag MMG96_RS01190 Protein ID WP_002436168.1
Coordinates 275126..275383 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG96_RS12985 270055..270165 + 111 Protein_229 YSIRK-type signal peptide-containing protein -
MMG96_RS12990 270787..271728 + 942 Protein_230 LPXTG cell wall anchor domain-containing protein -
MMG96_RS01170 (MMG96_01170) 271842..272600 + 759 WP_030059220.1 alpha/beta hydrolase family protein -
MMG96_RS01175 (MMG96_01175) 273143..274291 + 1149 WP_172969460.1 CapA family protein -
MMG96_RS01180 (MMG96_01180) 274355..274720 - 366 WP_002436243.1 DUF4870 domain-containing protein -
MMG96_RS01185 (MMG96_01185) 274864..275133 - 270 WP_002436254.1 Txe/YoeB family addiction module toxin Toxin
MMG96_RS01190 (MMG96_01190) 275126..275383 - 258 WP_002436168.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MMG96_RS01195 (MMG96_01195) 275568..276425 + 858 WP_002454139.1 ABC transporter substrate-binding protein -
MMG96_RS01200 (MMG96_01200) 276535..278175 - 1641 WP_030059216.1 alpha-keto acid decarboxylase family protein -
MMG96_RS01205 (MMG96_01205) 278348..278803 + 456 WP_002436214.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10524.00 Da        Isoelectric Point: 9.7885

>T237274 WP_002436254.1 NZ_CP092857:c275133-274864 [Staphylococcus capitis]
MSKFSVTFTAQAFKDYQYWQQHNQNYFKKVNALLKSIARDGCVDGIGKPEALKGNYEGYFSRRVSIEHRLIYKIKDDSIF
VVSCRFHYQ

Download         Length: 270 bp

>T237274 NZ_LR861805:c4480728-4480594 [Xanthomonas sp. CPBF 426]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCCGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9737.79 Da        Isoelectric Point: 4.1359

>AT237274 WP_002436168.1 NZ_CP092857:c275383-275126 [Staphylococcus capitis]
MPSVNYSNARQNFKELITKVNEDSVAYTITTKENENAVILAEKDYNAMLETMYLQSNLANVSHLNQSIMELNHNQTITIE
IDDNE

Download         Length: 258 bp

>AT237274 NZ_LR861805:c4480959-4480807 [Xanthomonas sp. CPBF 426]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCTGGCGC
CGGCAAGGACATGCAGGGCGCGGGCGAGAAGGTCGAGAAGAAGGCCGACAATTGCAGTGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SVT5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4EAU6

References