Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 571213..571913 Replicon chromosome
Accession NZ_CP092852
Organism Burkholderia contaminans strain B17-01563-1

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1E3FT75
Locus tag MMB18_RS19300 Protein ID WP_039357707.1
Coordinates 571617..571913 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A4R4BTY4
Locus tag MMB18_RS19295 Protein ID WP_039357704.1
Coordinates 571213..571614 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMB18_RS19275 (MMB18_19275) 566868..568220 - 1353 WP_039357693.1 LLM class flavin-dependent oxidoreductase -
MMB18_RS19280 (MMB18_19280) 568228..569277 - 1050 WP_039357696.1 LLM class flavin-dependent oxidoreductase -
MMB18_RS19285 (MMB18_19285) 569330..570277 - 948 WP_039357698.1 ABC transporter substrate-binding protein -
MMB18_RS19290 (MMB18_19290) 570334..570894 - 561 WP_039357701.1 GNAT family N-acetyltransferase -
MMB18_RS19295 (MMB18_19295) 571213..571614 - 402 WP_039357704.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
MMB18_RS19300 (MMB18_19300) 571617..571913 - 297 WP_039357707.1 type II toxin-antitoxin system MqsR family toxin Toxin
MMB18_RS19305 (MMB18_19305) 572017..573060 - 1044 WP_039357711.1 succinylglutamate desuccinylase/aspartoacylase family protein -
MMB18_RS19310 (MMB18_19310) 573312..573596 - 285 WP_039357714.1 hypothetical protein -
MMB18_RS19315 (MMB18_19315) 573838..575388 - 1551 WP_039357717.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11206.04 Da        Isoelectric Point: 8.0535

>T237269 WP_039357707.1 NZ_CP092852:c571913-571617 [Burkholderia contaminans]
MEKRTPHCKLPRVKALVETGQVRLTASAVLGARLLGFTEREALDVVLSLTDLDFHKSMTTYADHTIWQDVYRPFTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T237269 NZ_LR861803:66200-66499 [Xanthomonas euroxanthea]
ATGGCTGAAATAGTCTGGTCGGAGCCGGCGGTGGCCGACCTGGACGCGATTGCCGACTACATTGCACTTGAGGACGCAGC
CGCCGCAGCGGCACTGGTGAGACGGGTGGTTGCACATGTCGAGCAATTGGCCGAGCACCCGGAGAGCGGGAGCCGCCCGC
AGGAGCTCAAGCGCTCCCGCTACCGTCAAATCGTCGAACCACCGTGCCGCGTGTTCTACCGTGTGGATGGGCAGCGCGTC
GTCGTGGTTCACGTGATGCGCTCGGAGCGGTTACTCCGGAGAAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14649.94 Da        Isoelectric Point: 8.8304

>AT237269 WP_039357704.1 NZ_CP092852:c571614-571213 [Burkholderia contaminans]
MKCPACGAARLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAITEFNKQVNATIVDPKYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLAEVRAA

Download         Length: 402 bp

>AT237269 NZ_LR861803:65955-66212 [Xanthomonas euroxanthea]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGTCAGGCCACCGAACTCCTCGCTGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATTACCCAGCATGGTCTGCCCAGCGCATATCTGGTCGATGTCACCAGCTATGAGCGCCTGCAGCAGCGGATGGCGA
TCCTCGAAGGTATCGCCCGTGGTGAAATGGCGGTAGCGGAAGGCCGCAGCCTGAGCCACGAGCAGGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FT75

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BTY4

References