Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1494262..1494867 Replicon chromosome
Accession NZ_CP092844
Organism Burkholderia ambifaria strain Q53

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MK974_RS22635 Protein ID WP_269017121.1
Coordinates 1494262..1494540 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MK974_RS22640 Protein ID WP_175676950.1
Coordinates 1494553..1494867 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK974_RS22615 (MK974_22590) 1490990..1491472 - 483 WP_006755380.1 Lrp/AsnC family transcriptional regulator -
MK974_RS22620 (MK974_22595) 1491756..1492409 + 654 WP_269017118.1 LysE family translocator -
MK974_RS22625 (MK974_22600) 1492526..1493701 + 1176 WP_269017119.1 voltage-gated potassium channel protein -
MK974_RS22630 (MK974_22605) 1493750..1494181 + 432 WP_269017120.1 YqaA family protein -
MK974_RS22635 (MK974_22610) 1494262..1494540 + 279 WP_269017121.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MK974_RS22640 (MK974_22615) 1494553..1494867 + 315 WP_175676950.1 HigA family addiction module antitoxin Antitoxin
MK974_RS22645 (MK974_22620) 1494982..1496634 - 1653 WP_269017122.1 acyl-CoA synthetase -
MK974_RS22650 (MK974_22625) 1496851..1497675 + 825 WP_269017123.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-98)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10508.89 Da        Isoelectric Point: 7.7175

>T237254 WP_269017121.1 NZ_CP092844:1494262-1494540 [Burkholderia ambifaria]
MIQSFKCKDTRQLFETGRCRQFANIADVAMRRLTQLDNAVTLDALKSPPGNRFEALKGDRLGQYSIRINGQWRVCFTWGD
DGPADVEIADYH

Download         Length: 279 bp

>T237254 NZ_LR822061:2767950-2768054 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11771.43 Da        Isoelectric Point: 9.6536

>AT237254 WP_175676950.1 NZ_CP092844:1494553-1494867 [Burkholderia ambifaria]
MSRFKNGMRPVHPGEILREDYLIPLDMSANALAGALGVTAGRINDIVRERRGITADTALRLARYFGGDPQTWLNLQATYD
LKIAERDHGREIQKRIEPREFAHA

Download         Length: 315 bp

>AT237254 NZ_LR822061:c2768212-2768049 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References