Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1322986..1323686 Replicon chromosome
Accession NZ_CP092844
Organism Burkholderia ambifaria strain Q53

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag MK974_RS21930 Protein ID WP_269018440.1
Coordinates 1323390..1323686 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag MK974_RS21925 Protein ID WP_269018439.1
Coordinates 1322986..1323387 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK974_RS21895 (MK974_21875) 1318567..1319520 - 954 WP_269018436.1 ABC transporter substrate-binding protein -
MK974_RS21900 (MK974_21880) 1319587..1320147 - 561 WP_269018437.1 GNAT family N-acetyltransferase -
MK974_RS21905 (MK974_21885) 1320455..1321378 - 924 WP_269018438.1 recombination-associated protein RdgC -
MK974_RS21910 (MK974_21890) 1321352..1321537 + 186 WP_269018516.1 hypothetical protein -
MK974_RS21915 (MK974_21895) 1321618..1322688 + 1071 WP_269018478.1 zinc ribbon domain-containing protein -
MK974_RS21920 (MK974_21900) 1322614..1322828 - 215 Protein_1176 GNAT family N-acetyltransferase -
MK974_RS21925 (MK974_21905) 1322986..1323387 - 402 WP_269018439.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
MK974_RS21930 (MK974_21910) 1323390..1323686 - 297 WP_269018440.1 type II toxin-antitoxin system MqsR family toxin Toxin
MK974_RS21935 (MK974_21915) 1323795..1324838 - 1044 WP_269018441.1 succinylglutamate desuccinylase/aspartoacylase family protein -
MK974_RS21940 (MK974_21920) 1325086..1325361 - 276 WP_269018442.1 hypothetical protein -
MK974_RS21945 (MK974_21925) 1325633..1327183 - 1551 WP_269018443.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11154.90 Da        Isoelectric Point: 8.9136

>T237253 WP_269018440.1 NZ_CP092844:c1323686-1323390 [Burkholderia ambifaria]
MEKRTPHCKLSRVKALVEAGNVRMTTSAVLGARQLGFTPNEAIGIVMSLDTADFYKSMTTYADHTIWQDVYWRRTVNGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T237253 NZ_LR822061:2508328-2508594 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14622.93 Da        Isoelectric Point: 8.4917

>AT237253 WP_269018439.1 NZ_CP092844:c1323387-1322986 [Burkholderia ambifaria]
MKCPACGAAKLIRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDIDEATRLGEAIGEFNKQVNSTIVDPRFIAKVRKK
LMLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT237253 NZ_LR822061:2508077-2508328 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References