Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1220304..1220890 Replicon chromosome
Accession NZ_CP092827
Organism Pseudomonas sp. LS.1a

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag MKK04_RS05655 Protein ID WP_082810539.1
Coordinates 1220612..1220890 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MKK04_RS05650 Protein ID WP_207829464.1
Coordinates 1220304..1220603 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK04_RS05625 (MKK04_05625) 1216110..1216919 + 810 WP_207829470.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
MKK04_RS05630 (MKK04_05630) 1217031..1217441 - 411 WP_233693937.1 SufE family protein -
MKK04_RS05635 (MKK04_05635) 1217438..1218643 - 1206 WP_207829465.1 cysteine desulfurase -
MKK04_RS05640 (MKK04_05640) 1218764..1219798 - 1035 WP_063911503.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
MKK04_RS05645 (MKK04_05645) 1219830..1220177 - 348 WP_075043977.1 ArsC family reductase -
MKK04_RS05650 (MKK04_05650) 1220304..1220603 - 300 WP_207829464.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
MKK04_RS05655 (MKK04_05655) 1220612..1220890 - 279 WP_082810539.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKK04_RS05660 (MKK04_05660) 1221137..1222783 + 1647 WP_207829462.1 Na+/H+ antiporter -
MKK04_RS05665 (MKK04_05665) 1222935..1224131 - 1197 WP_207829461.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10526.90 Da        Isoelectric Point: 7.8928

>T237215 WP_082810539.1 NZ_CP092827:c1220890-1220612 [Pseudomonas sp. LS.1a]
MIRSFSCADTEALFTHGKTRRWSDIKSVAERKLAMLDAATELRDLRSPPGNRLEALSGNRAGQHSIRVNDQWRLCFIWTD
NGPINVEIVDYH

Download         Length: 279 bp

>T237215 NZ_LR796240:c971571-971233 [Treponema socranskii subsp. buccale]
ATGGTGAATTCAAATTATGTTCCCGATAGAGGCGATTTAGTTTGGCTTGATTTTAATCCGCAAGCAGGATATGAGCAGAA
AGGTCGTCGTCCTGCAATTTGCATTTCACAAAAAAGATACAATCAAAAAGCCGGACTTGCTTTATTTTGTCCTATTACGA
GCCATATAAAAGGTTATCCTTTTGAAATTGTATTGGATAATCATTCGATAAATGGCTGTATTCTTAGCGACCAAGTAAAG
AACCTTGATTATAAAAAAAGAAGTTGTGATTTTATAGAAAAAACAACAGAAGAAGAGATAAATGCTGTTGTAGATAATAT
AAAGTTGTTGATTGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10876.55 Da        Isoelectric Point: 7.1670

>AT237215 WP_207829464.1 NZ_CP092827:c1220603-1220304 [Pseudomonas sp. LS.1a]
MLKNGMRPIHPGEVLREDFQKEMGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQQHGDKIIGSVQRLVA

Download         Length: 300 bp

>AT237215 NZ_LR796240:c971798-971565 [Treponema socranskii subsp. buccale]
ATGCAGGTTGTAGTTCAGAAATGGGGTAATAGTCTCGGATTTAGAATACCCTCTCTTTGGGCAAAAGATAATAATGTAAA
GAATGGAAGCAAAATAGAAGTACTCGCAGAAAAAGGAAAAATAGTAATTCTTCCTCAGAAAAAAACTCTTGATGATATGC
TGGCAATGGTTACTTCTGAAAACGTTCATTCGGAAATCTCGACAGATTATTCAGTAGGTAACGAAGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References