Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2430289..2430806 | Replicon | chromosome |
| Accession | NZ_CP092825 | ||
| Organism | Staphylococcus aureus strain GY8 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | MK796_RS12045 | Protein ID | WP_000113263.1 |
| Coordinates | 2430289..2430555 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MK796_RS12050 | Protein ID | WP_000584499.1 |
| Coordinates | 2430555..2430806 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MK796_RS12015 (2425549) | 2425549..2426085 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| MK796_RS12020 (2426498) | 2426498..2427322 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| MK796_RS12025 (2427526) | 2427526..2427708 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| MK796_RS12030 (2427795) | 2427795..2428262 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| MK796_RS12035 (2428448) | 2428448..2429995 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MK796_RS12040 (2430183) | 2430183..2430254 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| MK796_RS12045 (2430289) | 2430289..2430555 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| MK796_RS12050 (2430555) | 2430555..2430806 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MK796_RS12055 (2430978) | 2430978..2431069 | - | 92 | Protein_2330 | hypothetical protein | - |
| MK796_RS12060 (2431076) | 2431076..2431675 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MK796_RS12065 (2431694) | 2431694..2432056 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| MK796_RS12070 (2432311) | 2432311..2433561 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| MK796_RS12075 (2433658) | 2433658..2434389 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| MK796_RS12080 (2434386) | 2434386..2435105 | - | 720 | WP_241043427.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T237212 WP_000113263.1 NZ_CP092825:c2430555-2430289 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T237212 NZ_LR792684:200227-200577 [Kyrpidia spormannii]
GTGAACATCAAGCGAGGGGATATTTTTTTTGCGAATCTATCCCCGGTGGTCGGTTCTGAACAAGGGGGCTTCCGGCCGGT
ATTGGTGATCCAAAACGATATCGGAAACCGGTTTAGCCCGACAGTCATCGTCGCGGCAATCACCGCCCAGATTCAGAAGG
CCAAGCTGCCCACCCACGTGGAGATTGATGCGAAAACCTACGGACTGGATCGGGATTCGGTCATCCTCCTGGAGCAGATT
CGCACCATTGATAAGCAGCGGTTGACGGATAAGATTACGCACCTGGACGATGAGATGATGAGCAAGGTCAACGAGTCGCT
CATGATCAGCCTGGGGTTGATCGATTTTTAG
GTGAACATCAAGCGAGGGGATATTTTTTTTGCGAATCTATCCCCGGTGGTCGGTTCTGAACAAGGGGGCTTCCGGCCGGT
ATTGGTGATCCAAAACGATATCGGAAACCGGTTTAGCCCGACAGTCATCGTCGCGGCAATCACCGCCCAGATTCAGAAGG
CCAAGCTGCCCACCCACGTGGAGATTGATGCGAAAACCTACGGACTGGATCGGGATTCGGTCATCCTCCTGGAGCAGATT
CGCACCATTGATAAGCAGCGGTTGACGGATAAGATTACGCACCTGGACGATGAGATGATGAGCAAGGTCAACGAGTCGCT
CATGATCAGCCTGGGGTTGATCGATTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT237212 WP_000584499.1 NZ_CP092825:c2430806-2430555 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT237212 NZ_LR792684:199924-200223 [Kyrpidia spormannii]
ATGGCGAGTGTCCCGGAGGTGCTTGGGTTGTCCGAGACAAAGCGGATTATGATTAGTGTTCCGAGTCACCTGCTCCAGGA
AGTCGACGGAATTGCAGAAAGAGAGAATTCCAATCGAAGCGAGGTCATTCGCCAAGCGATGAGACTGTATTTGGAAGAGC
GTAAAAAGGAACGCATTCGCGAGTTGATGCAGCGAGGTTATGTGGAGATGGCGAAGATTAACCTTTATATTGCGTCGGAG
GCGTTTTACGCCGAAGAGGAGGCGGGTTCGACCCTAGATCGACTAGTAAGCGGGGTGTGA
ATGGCGAGTGTCCCGGAGGTGCTTGGGTTGTCCGAGACAAAGCGGATTATGATTAGTGTTCCGAGTCACCTGCTCCAGGA
AGTCGACGGAATTGCAGAAAGAGAGAATTCCAATCGAAGCGAGGTCATTCGCCAAGCGATGAGACTGTATTTGGAAGAGC
GTAAAAAGGAACGCATTCGCGAGTTGATGCAGCGAGGTTATGTGGAGATGGCGAAGATTAACCTTTATATTGCGTCGGAG
GCGTTTTACGCCGAAGAGGAGGCGGGTTCGACCCTAGATCGACTAGTAAGCGGGGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|