Detailed information of TA system TA237203

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 367845..368293
• Replicon: chromosome
• Accession: NZ_CP092825
• Organism: Staphylococcus aureus strain GY8

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A853P973
• Locus tag: MK796_RS01750
• Protein ID: WP_000387656.1
• Coordinates: 367991..368293 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	367845..367911 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MK796_RS01720 (362946)	362946..366626	+	3681	WP_000582140.1	phage tail spike protein	-
MK796_RS01725 (366613)	366613..366765	+	153	WP_001181555.1	hypothetical protein	-
MK796_RS01730 (366812)	366812..367099	+	288	WP_001040257.1	hypothetical protein	-
MK796_RS01735 (367157)	367157..367453	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
MK796_RS01740 (367685)	367685..367792	+	108	WP_000253688.1	putative holin-like toxin	-
- (367845)	367845..367911	-	67	NuclAT_0	-	Antitoxin
- (367845)	367845..367911	-	67	NuclAT_0	-	Antitoxin
- (367845)	367845..367911	-	67	NuclAT_0	-	Antitoxin
- (367845)	367845..367911	-	67	NuclAT_0	-	Antitoxin
MK796_RS01745 (367836)	367836..367940	-	105	Protein_347	hypothetical protein	-
MK796_RS01750 (367991)	367991..368293	+	303	WP_000387656.1	phage holin	Toxin
MK796_RS01755 (368305)	368305..369759	+	1455	WP_103067904.1	N-acetylmuramoyl-L-alanine amidase	-
MK796_RS01760 (370004)	370004..370156	+	153	WP_001788502.1	hypothetical protein	-
MK796_RS01765 (370227)	370227..370337	+	111	WP_000139423.1	hypothetical protein	-
MK796_RS01770 (370339)	370339..370524	+	186	WP_001286805.1	hypothetical protein	-
MK796_RS01775 (370871)	370871..371920	+	1050	WP_000405105.1	hypothetical protein	-
MK796_RS01780 (372018)	372018..372200	+	183	WP_000990948.1	hypothetical protein	-
MK796_RS01785 (372197)	372197..372880	+	684	WP_000180531.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	329549..370524	40975

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11177.94 Da
• Isoelectric Point: 9.6587

>T237203 WP_000387656.1 NZ_CP092825:367991-368293 [Staphylococcus aureus]
MEAKVMARYVVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T237203 NZ_LR792628:c4984568-4984284 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT237203 NZ_CP092825:c367911-367845 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Structures

Toxin

• AlphaFold DB: A0A853P973

Antitoxin