Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 367685..367911 Replicon chromosome
Accession NZ_CP092825
Organism Staphylococcus aureus strain GY8

Toxin (Protein)


Gene name SprG2 Uniprot ID A0A0E0VS87
Locus tag MK796_RS01740 Protein ID WP_000253688.1
Coordinates 367685..367792 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 367845..367911 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK796_RS01720 (362946) 362946..366626 + 3681 WP_000582140.1 phage tail spike protein -
MK796_RS01725 (366613) 366613..366765 + 153 WP_001181555.1 hypothetical protein -
MK796_RS01730 (366812) 366812..367099 + 288 WP_001040257.1 hypothetical protein -
MK796_RS01735 (367157) 367157..367453 + 297 WP_000539688.1 DUF2951 domain-containing protein -
MK796_RS01740 (367685) 367685..367792 + 108 WP_000253688.1 putative holin-like toxin Toxin
- (367845) 367845..367911 - 67 NuclAT_0 - Antitoxin
- (367845) 367845..367911 - 67 NuclAT_0 - Antitoxin
- (367845) 367845..367911 - 67 NuclAT_0 - Antitoxin
- (367845) 367845..367911 - 67 NuclAT_0 - Antitoxin
MK796_RS01745 (367836) 367836..367940 - 105 Protein_347 hypothetical protein -
MK796_RS01750 (367991) 367991..368293 + 303 WP_000387656.1 phage holin -
MK796_RS01755 (368305) 368305..369759 + 1455 WP_103067904.1 N-acetylmuramoyl-L-alanine amidase -
MK796_RS01760 (370004) 370004..370156 + 153 WP_001788502.1 hypothetical protein -
MK796_RS01765 (370227) 370227..370337 + 111 WP_000139423.1 hypothetical protein -
MK796_RS01770 (370339) 370339..370524 + 186 WP_001286805.1 hypothetical protein -
MK796_RS01775 (370871) 370871..371920 + 1050 WP_000405105.1 hypothetical protein -
MK796_RS01780 (372018) 372018..372200 + 183 WP_000990948.1 hypothetical protein -
MK796_RS01785 (372197) 372197..372880 + 684 WP_000180531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 329549..370524 40975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3817.78 Da        Isoelectric Point: 10.4997

>T237200 WP_000253688.1 NZ_CP092825:367685-367792 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLSHKK

Download         Length: 108 bp

>T237200 NZ_LR792628:c3181121-3181019 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 67 bp

>AT237200 NZ_CP092825:c367911-367845 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VS87

Antitoxin

Download structure file

References