Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 329088..329674 Replicon chromosome
Accession NZ_CP092793
Organism Klebsiella pneumoniae strain XH1507

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag ML258_RS01530 Protein ID WP_002920800.1
Coordinates 329306..329674 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag ML258_RS01525 Protein ID WP_002920802.1
Coordinates 329088..329309 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ML258_RS01505 (ML258_01505) 325245..326171 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
ML258_RS01510 (ML258_01510) 326168..327445 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
ML258_RS01515 (ML258_01515) 327442..328209 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
ML258_RS01520 (ML258_01520) 328211..328924 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
ML258_RS01525 (ML258_01525) 329088..329309 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ML258_RS01530 (ML258_01530) 329306..329674 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ML258_RS01535 (ML258_01535) 329947..331263 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
ML258_RS01540 (ML258_01540) 331370..332257 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
ML258_RS01545 (ML258_01545) 332254..333099 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
ML258_RS01550 (ML258_01550) 333101..334171 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 326168..334908 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T237172 WP_002920800.1 NZ_CP092793:329306-329674 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T237172 NZ_LR778301:c2905754-2905503 [Denitratisoma oestradiolicum]
ATGGATGCGATTACCTACACTACAGCTCGCGCGAACTTGGCGACTACCATGGATCGGGTGTGCAACGACCACGAGGCGCT
GATAATTACCCGCAACGGCGAACAGGCCGTTGTGATGCTTTCGCTCGAAGATTTCAAGGCGCTTGAAGAAACGGCCTACC
TTCTGCGCACACCGGCCAACGCCAAGCGCCTGCTCTCGGCGATTGCTCAGTTGAACGCTGGGAAAGGTGTTGAGCGGAAG
CTGGCCAAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT237172 WP_002920802.1 NZ_CP092793:329088-329309 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT237172 NZ_LR778301:c2905506-2905252 [Denitratisoma oestradiolicum]
GTGAAGCTGATTTTTTCTGACGAGGCATGGGAAGACTACCTGTATTGGCAGAAGCAAGACAAGCGCATGGTGGAACGAAT
CAACAAGCTGATTCGGGAAACGGAGCGCGAGCCATTTAACGGCGTAGGCAAGCCGGAGCCGTTGAAGCACGCGCTATCGG
GATTTTGGTCTCGGCGGATCACAGATGAACATCGCATGGTGTATCGCGTCGTGAACGATGCGCTGGAAATTGTGCAACTC
CGTTTCCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References