Detailed information of TA system TA237140

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2558134..2558532
• Replicon: chromosome
• Accession: NZ_CP092784
• Organism: Enterococcus sp. LX10

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MKZ30_RS12050
• Protein ID: WP_023894767.1
• Coordinates: 2558134..2558238 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2558390..2558532 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKZ30_RS12035 (2553447)	2553447..2554160	-	714	WP_002354877.1	trehalose operon repressor	-
MKZ30_RS12040 (2554421)	2554421..2557165	+	2745	WP_129226010.1	glycosyl hydrolase family 65 protein	-
MKZ30_RS12045 (2557180)	2557180..2557830	+	651	WP_016614233.1	beta-phosphoglucomutase	-
- (2558014)	2558014..2558201	+	188	NuclAT_4	-	-
MKZ30_RS12050 (2558134)	2558134..2558238	-	105	WP_023894767.1	putative holin-like toxin	Toxin
- (2558390)	2558390..2558532	+	143	NuclAT_10	-	Antitoxin
MKZ30_RS13325 (2558623)	2558623..2558745	-	123	WP_002419628.1	hypothetical protein	-
MKZ30_RS12055 (2559538)	2559538..2560509	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
MKZ30_RS12060 (2560684)	2560684..2561121	-	438	WP_010715474.1	peptide-methionine (R)-S-oxide reductase MsrB	-
MKZ30_RS12065 (2561254)	2561254..2561808	-	555	WP_033601100.1	nucleoside triphosphate pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T237140 WP_023894767.1 NZ_CP092784:c2558238-2558134 [Enterococcus sp. LX10]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

>T237140 NZ_LR778152:3680581-3680688 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 143 bp

>AT237140 NZ_CP092784:2558390-2558532 [Enterococcus sp. LX10]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACCGATCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Antitoxin