Detailed information of TA system TA237134

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 457859..458091
• Replicon: chromosome
• Accession: NZ_CP092784
• Organism: Enterococcus sp. LX10

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: C7CXQ5
• Locus tag: MKZ30_RS02265
• Protein ID: WP_002355568.1
• Coordinates: 457859..457975 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	457886..458091 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKZ30_RS02255 (453297)	453297..455555	+	2259	WP_002363179.1	DNA helicase PcrA	-
MKZ30_RS02260 (455681)	455681..457711	+	2031	WP_002375948.1	NAD-dependent DNA ligase LigA	-
MKZ30_RS02265 (457859)	457859..457975	+	117	WP_002355568.1	putative holin-like toxin	Toxin
- (457886)	457886..458091	-	206	NuclAT_3	-	Antitoxin
- (457958)	457958..458093	-	136	NuclAT_9	-	-
- (457958)	457958..458113	-	156	NuclAT_7	-	-
MKZ30_RS02270 (458293)	458293..458598	+	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
MKZ30_RS02275 (458598)	458598..460067	+	1470	WP_002419989.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
MKZ30_RS02280 (460067)	460067..461497	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
MKZ30_RS02285 (461516)	461516..462604	+	1089	WP_002383001.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4065.93 Da
• Isoelectric Point: 5.9482

>T237134 WP_002355568.1 NZ_CP092784:457859-457975 [Enterococcus sp. LX10]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Nucleotide

• Length: 117 bp

>T237134 NZ_LR778152:c2369936-2369538 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 206 bp

>AT237134 NZ_CP092784:c458091-457886 [Enterococcus sp. LX10]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: A0A1B4XLM6

Antitoxin