Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 327608..328194 Replicon chromosome
Accession NZ_CP092765
Organism Klebsiella pneumoniae strain bat15

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag MKZ43_RS01515 Protein ID WP_002920800.1
Coordinates 327826..328194 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag MKZ43_RS01510 Protein ID WP_002920802.1
Coordinates 327608..327829 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ43_RS01490 (MKZ43_01490) 323765..324691 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MKZ43_RS01495 (MKZ43_01495) 324688..325965 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
MKZ43_RS01500 (MKZ43_01500) 325962..326729 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MKZ43_RS01505 (MKZ43_01505) 326731..327444 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MKZ43_RS01510 (MKZ43_01510) 327608..327829 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKZ43_RS01515 (MKZ43_01515) 327826..328194 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MKZ43_RS01520 (MKZ43_01520) 328467..329783 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MKZ43_RS01525 (MKZ43_01525) 329890..330777 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MKZ43_RS01530 (MKZ43_01530) 330774..331619 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MKZ43_RS01535 (MKZ43_01535) 331621..332691 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 325962..333428 7466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T237106 WP_002920800.1 NZ_CP092765:327826-328194 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T237106 NZ_LR778151:c52838-52560 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT237106 WP_002920802.1 NZ_CP092765:327608-327829 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT237106 NZ_LR778151:c53101-52841 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References