Detailed information of TA system TA237043

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 58879..59148
• Replicon: plasmid unnamed1
• Accession: NZ_CP092718
• Organism: Klebsiella pneumoniae strain HvKp-su1

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MKX18_RS27560
• Protein ID: WP_001372321.1
• Coordinates: 59023..59148 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	58879..58944 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKX18_RS27530	54589..55116	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
MKX18_RS27535	55174..55407	+	234	WP_000006003.1	DUF905 family protein	-
MKX18_RS27540	55468..57491	+	2024	Protein_80	ParB/RepB/Spo0J family partition protein	-
MKX18_RS27545	57560..57994	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
MKX18_RS27550	57991..58710	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	58722..58946	+	225	NuclAT_0	-	-
-	58722..58946	+	225	NuclAT_0	-	-
-	58722..58946	+	225	NuclAT_0	-	-
-	58722..58946	+	225	NuclAT_0	-	-
-	58879..58944	-	66	-	-	Antitoxin
MKX18_RS27555	58932..59081	+	150	Protein_83	plasmid maintenance protein Mok	-
MKX18_RS27560	59023..59148	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MKX18_RS27565	59467..59763	-	297	Protein_85	hypothetical protein	-
MKX18_RS27570	60063..60359	+	297	WP_001272251.1	hypothetical protein	-
MKX18_RS27575	60470..61291	+	822	WP_001234445.1	DUF932 domain-containing protein	-
MKX18_RS27580	61588..62235	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
MKX18_RS27585	62512..62895	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MKX18_RS27590	63086..63772	+	687	WP_015059009.1	PAS domain-containing protein	-
MKX18_RS27595	63866..64093	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2	-	1..133346	133346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T237043 WP_001372321.1 NZ_CP092718:59023-59148 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T237043 NZ_LR778147:c3239927-3239751 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT237043 NZ_CP092718:c58944-58879 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin