Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355220..355866 Replicon chromosome
Accession NZ_CP092717
Organism Klebsiella pneumoniae strain HvKp-su1

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag MKX18_RS01640 Protein ID WP_002920560.1
Coordinates 355220..355567 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag MKX18_RS01645 Protein ID WP_002920557.1
Coordinates 355567..355866 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKX18_RS01630 (MKX18_01630) 351146..352579 + 1434 WP_002920564.1 glycogen synthase GlgA -
MKX18_RS01635 (MKX18_01635) 352597..355044 + 2448 WP_002920561.1 glycogen phosphorylase -
MKX18_RS01640 (MKX18_01640) 355220..355567 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKX18_RS01645 (MKX18_01645) 355567..355866 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
MKX18_RS01650 (MKX18_01650) 355929..357437 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
MKX18_RS01655 (MKX18_01655) 357642..357971 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
MKX18_RS01660 (MKX18_01660) 358022..358852 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
MKX18_RS01665 (MKX18_01665) 358902..359660 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T237023 WP_002920560.1 NZ_CP092717:355220-355567 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T237023 NZ_LR778146:3676827-3676934 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT237023 WP_002920557.1 NZ_CP092717:355567-355866 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT237023 NZ_LR778146:c3676779-3676713 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References