Detailed information of TA system TA236998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3699927..3700149
• Replicon: chromosome
• Accession: NZ_CP092702
• Organism: Escherichia coli strain S-P-C-029.01

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: MJ592_RS18065
• Protein ID: WP_000141634.1
• Coordinates: 3699927..3700034 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3700083..3700149 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ592_RS18040	3695180..3695908	-	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-
MJ592_RS18045	3695944..3696132	-	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
MJ592_RS18050	3696405..3697976	+	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
MJ592_RS18055	3697973..3698164	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
MJ592_RS18060	3698161..3699840	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
MJ592_RS18065	3699927..3700034	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3700083..3700149	+	67	-	-	Antitoxin
MJ592_RS18070	3700510..3701781	+	1272	WP_001295225.1	aromatic amino acid transport family protein	-
MJ592_RS18075	3701811..3702815	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
MJ592_RS18080	3702812..3703795	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
MJ592_RS18085	3703806..3704708	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T236998 WP_000141634.1 NZ_CP092702:c3700034-3699927 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T236998 NZ_LR778145:c937800-937336 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT236998 NZ_CP092702:3700083-3700149 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin