Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3167830..3168523 Replicon chromosome
Accession NZ_CP092702
Organism Escherichia coli strain S-P-C-029.01

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MJ592_RS15455 Protein ID WP_000415584.1
Coordinates 3168227..3168523 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MJ592_RS15450 Protein ID WP_000650107.1
Coordinates 3167830..3168225 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ592_RS15440 (3163694) 3163694..3165952 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
MJ592_RS15445 (3166090) 3166090..3167697 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MJ592_RS15450 (3167830) 3167830..3168225 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MJ592_RS15455 (3168227) 3168227..3168523 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MJ592_RS15460 (3168728) 3168728..3169210 - 483 WP_000183505.1 GyrI-like domain-containing protein -
MJ592_RS15465 (3169263) 3169263..3169655 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MJ592_RS15470 (3169807) 3169807..3170466 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
MJ592_RS15475 (3170463) 3170463..3171812 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MJ592_RS15480 (3171858) 3171858..3172190 - 333 WP_000917684.1 DUF2645 family protein -
MJ592_RS15485 (3172509) 3172509..3173090 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MJ592_RS15490 (3173121) 3173121..3173435 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T236995 WP_000415584.1 NZ_CP092702:c3168523-3168227 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T236995 NZ_LR778143:4270187-4270294 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT236995 WP_000650107.1 NZ_CP092702:c3168225-3167830 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT236995 NZ_LR778143:c4270134-4270073 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References