Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4631481..4632235 Replicon chromosome
Accession NZ_CP092690
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)


Gene name higB Uniprot ID A0A5I4V816
Locus tag MKV11_RS22570 Protein ID WP_017465947.1
Coordinates 4631481..4631792 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MKV11_RS22575 Protein ID WP_017465948.1
Coordinates 4631789..4632235 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKV11_RS22540 (4627139) 4627139..4628041 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
MKV11_RS22545 (4628038) 4628038..4628673 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
MKV11_RS22550 (4628670) 4628670..4629599 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
MKV11_RS22555 (4629646) 4629646..4629936 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
MKV11_RS22560 (4629937) 4629937..4630248 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
MKV11_RS22565 (4630466) 4630466..4631395 + 930 WP_001127708.1 alpha/beta hydrolase -
MKV11_RS22570 (4631481) 4631481..4631792 + 312 WP_017465947.1 type II toxin-antitoxin system HigB family toxin Toxin
MKV11_RS22575 (4631789) 4631789..4632235 + 447 WP_017465948.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
MKV11_RS22580 (4632250) 4632250..4633191 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
MKV11_RS22585 (4633236) 4633236..4633673 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
MKV11_RS22590 (4633670) 4633670..4634542 - 873 WP_000921423.1 virulence factor BrkB family protein -
MKV11_RS22595 (4634536) 4634536..4635135 - 600 WP_001621364.1 glucose-1-phosphatase -
MKV11_RS22600 (4635326) 4635326..4636129 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
MKV11_RS22605 (4636163) 4636163..4637059 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12384.31 Da        Isoelectric Point: 9.2528

>T236961 WP_017465947.1 NZ_CP092690:4631481-4631792 [Salmonella enterica subsp. enterica serovar Thompson]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T236961 NZ_LR778142:c1780964-1780857 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16736.06 Da        Isoelectric Point: 6.6451

>AT236961 WP_017465948.1 NZ_CP092690:4631789-4632235 [Salmonella enterica subsp. enterica serovar Thompson]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT236961 NZ_LR778142:1781017-1781078 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I4V816

Antitoxin

Source ID Structure

References