Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1195087..1195862 Replicon chromosome
Accession NZ_CP092656
Organism Klebsiella pneumoniae strain NB5

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag MJ642_RS09030 Protein ID WP_004150910.1
Coordinates 1195377..1195862 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag MJ642_RS09025 Protein ID WP_004150912.1
Coordinates 1195087..1195380 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ642_RS09005 1190295..1190897 - 603 WP_002916735.1 short chain dehydrogenase -
MJ642_RS09010 1190995..1191906 + 912 WP_004188550.1 LysR family transcriptional regulator -
MJ642_RS09015 1191907..1193055 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
MJ642_RS09020 1193066..1194442 - 1377 WP_004217775.1 cystathionine beta-synthase -
MJ642_RS09025 1195087..1195380 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
MJ642_RS09030 1195377..1195862 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
MJ642_RS09035 1196566..1197159 + 594 WP_004188553.1 hypothetical protein -
MJ642_RS09040 1197256..1197472 + 217 Protein_1125 transposase -
MJ642_RS09045 1198078..1198950 + 873 WP_004188557.1 ParA family protein -
MJ642_RS09050 1198950..1199333 + 384 WP_004150906.1 hypothetical protein -
MJ642_RS09055 1199326..1200693 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1197256..1197408 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T236908 WP_004150910.1 NZ_CP092656:1195377-1195862 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T236908 NZ_LR777867:101411-101674 [Corynebacterium diphtheriae]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGCCTACGACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT236908 WP_004150912.1 NZ_CP092656:1195087-1195380 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT236908 NZ_LR777867:101191-101427 [Corynebacterium diphtheriae]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGCGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References