Detailed information of TA system TA023688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1612727..1613193
• Replicon: chromosome
• Accession: NC_012560
• Organism: Azotobacter vinelandii DJ

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: AVIN_RS07490
• Protein ID: WP_175555961.1
• Coordinates: 1612939..1613193 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: AVIN_RS07485
• Protein ID: WP_012700258.1
• Coordinates: 1612727..1612936 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVIN_RS07480	1608506..1612630	+	4125	WP_012700257.1	ATP-dependent RNA helicase HrpA	-
AVIN_RS07485	1612727..1612936	+	210	WP_012700258.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AVIN_RS07490	1612939..1613193	+	255	WP_175555961.1	Txe/YoeB family addiction module toxin	Toxin
AVIN_RS07495	1613244..1613657	+	414	WP_041807078.1	MarR family winged helix-turn-helix transcriptional regulator	-
AVIN_RS07500	1613713..1614909	+	1197	WP_085930866.1	MFS transporter	-
AVIN_RS07505	1615229..1615597	-	369	WP_012700263.1	hypothetical protein	-
AVIN_RS07510	1615723..1616226	+	504	WP_012700264.1	hypothetical protein	-
AVIN_RS07515	1616601..1617026	+	426	WP_012700265.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10023.50 Da
• Isoelectric Point: 8.9238

>T23688 WP_175555961.1 NC_012560:1612939-1613193 [Azotobacter vinelandii DJ]
MNILFTPEVWDDYLWFQQNDKAGLKRINLLIREAQRDPFGGLGKPEPLKHDLSGFWSRRVSEEHRLVYKVNGDAPQIVMC
RYRY

Nucleotide

• Length: 255 bp

>T23688 NC_012560:1612939-1613193 [Azotobacter vinelandii DJ]
CTGAATATTCTCTTCACGCCCGAGGTTTGGGACGACTATCTGTGGTTCCAGCAGAACGACAAGGCCGGGCTGAAACGGAT
CAACCTGCTGATCCGGGAGGCGCAACGCGATCCTTTCGGTGGCCTGGGCAAACCGGAACCTTTGAAACACGACCTCAGTG
GTTTCTGGTCGCGTCGCGTCAGCGAGGAACATCGATTGGTCTACAAGGTGAACGGCGATGCCCCGCAGATCGTGATGTGC
CGTTATCGCTACTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7802.88 Da
• Isoelectric Point: 4.7405

>AT23688 WP_012700258.1 NC_012560:1612727-1612936 [Azotobacter vinelandii DJ]
MERVNDDRAPILITRQKGEPVVMMSLADYNAFEETAYLLRSPANAERLIRSIANLRAGKAEPRTLVDED

Nucleotide

• Length: 210 bp

>AT23688 NC_012560:1612727-1612936 [Azotobacter vinelandii DJ]
ATGGAGCGGGTGAACGACGACCGCGCGCCCATCCTGATCACCCGGCAGAAAGGAGAGCCGGTCGTCATGATGTCCCTGGC
CGATTACAACGCTTTCGAAGAGACGGCCTATCTGCTGCGTTCGCCCGCCAATGCCGAACGACTGATCCGCTCGATCGCCA
ATCTGCGGGCAGGGAAGGCGGAGCCGCGAACGCTCGTCGACGAAGATTGA