Detailed information of TA system TA023684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1492736..1493388
• Replicon: chromosome
• Accession: NC_012559
• Organism: Laribacter hongkongensis HLHK9

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LHK_RS07095
• Protein ID: WP_012697021.1
• Coordinates: 1492736..1493080 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: C1D7U6
• Locus tag: LHK_RS07100
• Protein ID: WP_012697022.1
• Coordinates: 1493077..1493388 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK_RS07080	1488623..1489084	+	462	WP_012697017.1	hypothetical protein	-
LHK_RS16485	1489097..1489339	+	243	WP_012697018.1	hypothetical protein	-
LHK_RS07085	1489406..1490011	+	606	WP_012697019.1	hypothetical protein	-
LHK_RS15895	1490011..1490829	+	819	Protein_1425	hypothetical protein	-
LHK_RS15260	1491388..1492635	+	1248	Protein_1426	hypothetical protein	-
LHK_RS07095	1492736..1493080	+	345	WP_012697021.1	toxin	Toxin
LHK_RS07100	1493077..1493388	+	312	WP_012697022.1	XRE family transcriptional regulator	Antitoxin
LHK_RS07105	1493504..1493794	-	291	WP_012697023.1	HigA family addiction module antidote protein	-
LHK_RS07110	1493804..1494085	-	282	WP_012697024.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LHK_RS07115	1494202..1494801	+	600	WP_012697025.1	hypothetical protein	-
LHK_RS15265	1494812..1496962	+	2151	WP_012697026.1	hypothetical protein	-
LHK_RS07125	1496962..1497459	+	498	WP_012697027.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13217.93 Da
• Isoelectric Point: 9.6379

>T23684 WP_012697021.1 NC_012559:1492736-1493080 [Laribacter hongkongensis HLHK9]
VKASFIELPAFARYRQGYLDDDAFRELQQYLLDRPDAGDVIQGTGGLRKVRFADARRGKGKRGGIRVIYYWWLGGNQFWL
FTLYDKDEAGDLSHDERKAIKAMLEREINARSQT

Nucleotide

• Length: 345 bp

>T23684 NC_012559:1492736-1493080 [Laribacter hongkongensis HLHK9]
GTGAAAGCTTCATTCATCGAGTTACCGGCATTTGCACGTTATCGTCAGGGCTATCTTGACGATGATGCGTTTCGTGAGTT
GCAGCAGTACTTGCTTGATCGGCCGGATGCAGGAGATGTCATACAGGGAACAGGTGGCCTGCGCAAAGTAAGGTTTGCTG
ATGCCCGGCGTGGCAAAGGCAAGCGTGGCGGTATCAGGGTCATTTACTATTGGTGGCTTGGCGGGAATCAGTTCTGGCTG
TTTACGCTCTATGACAAGGATGAAGCAGGTGACCTGAGCCACGATGAGCGCAAAGCAATCAAGGCTATGCTGGAACGCGA
AATCAATGCAAGGAGTCAGACATGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11999.76 Da
• Isoelectric Point: 10.8110

>AT23684 WP_012697022.1 NC_012559:1493077-1493388 [Laribacter hongkongensis HLHK9]
MKRNLFAELTEGMDALRDEREGKVTLRQHTAERKEAPTVSAQEVLALRTRLHLSRPVFARYLRTNERTLENWEQGRAKPN
AQAALLIRMVERYPDTVQRLATI

Nucleotide

• Length: 312 bp

>AT23684 NC_012559:1493077-1493388 [Laribacter hongkongensis HLHK9]
ATGAAGCGCAATCTGTTTGCAGAACTTACCGAAGGCATGGATGCGCTCCGTGATGAGCGCGAAGGCAAAGTGACGTTACG
CCAGCACACGGCAGAGCGTAAAGAAGCCCCGACAGTGAGCGCGCAAGAGGTTCTGGCCCTGCGTACCCGGTTACATCTCT
CTCGCCCGGTATTTGCACGCTATCTGCGTACGAACGAACGGACGCTGGAAAACTGGGAGCAAGGACGGGCCAAGCCTAAT
GCCCAGGCCGCTCTCCTGATCCGGATGGTGGAGCGTTATCCGGATACCGTACAGCGACTCGCAACGATTTGA

Structures

Antitoxin

• AlphaFold DB: C1D7U6