Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1775068..1775570 | Replicon | chromosome |
| Accession | NZ_CP092639 | ||
| Organism | Escherichia coli strain HS | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A7I6H4L3 |
| Locus tag | MJ392_RS08425 | Protein ID | WP_000767831.1 |
| Coordinates | 1775316..1775570 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | MJ392_RS08420 | Protein ID | WP_001259255.1 |
| Coordinates | 1775068..1775319 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MJ392_RS08395 (1770245) | 1770245..1771312 | - | 1068 | WP_000080094.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| MJ392_RS08400 (1771312) | 1771312..1772382 | - | 1071 | WP_000108945.1 | histidinol-phosphate transaminase | - |
| MJ392_RS08405 (1772379) | 1772379..1773683 | - | 1305 | WP_001565639.1 | histidinol dehydrogenase | - |
| MJ392_RS08410 (1773689) | 1773689..1774588 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| MJ392_RS08415 (1774734) | 1774734..1774784 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| MJ392_RS08420 (1775068) | 1775068..1775319 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| MJ392_RS08425 (1775316) | 1775316..1775570 | + | 255 | WP_000767831.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| MJ392_RS08430 (1775653) | 1775653..1776477 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| MJ392_RS08435 (1776523) | 1776523..1777452 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| MJ392_RS08440 (1777667) | 1777667..1777729 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| MJ392_RS08445 (1777719) | 1777719..1779077 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| MJ392_RS08450 (1779256) | 1779256..1780314 | + | 1059 | WP_000492321.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| MJ392_RS08455 (1780328) | 1780328..1780555 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10231.67 Da Isoelectric Point: 8.8202
>T236826 WP_000767831.1 NZ_CP092639:1775316-1775570 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY
Download Length: 255 bp
>T236826 NZ_LR740758:2080583-2080957 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTTCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTTCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT236826 WP_001259255.1 NZ_CP092639:1775068-1775319 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT236826 NZ_LR740758:2080126-2080494 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7I6H4L3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 2A6Q | |
| AlphaFold DB | A0A7U9LNR0 |