Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1207253..1207910 | Replicon | chromosome |
| Accession | NZ_CP092635 | ||
| Organism | Enterobacter cloacae strain EFN743 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A421IAD7 |
| Locus tag | MKZ88_RS05885 | Protein ID | WP_014832979.1 |
| Coordinates | 1207611..1207910 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MKZ88_RS05880 | Protein ID | WP_038980942.1 |
| Coordinates | 1207253..1207600 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKZ88_RS05845 (MKZ88_05845) | 1202462..1203064 | - | 603 | WP_013098397.1 | short chain dehydrogenase | - |
| MKZ88_RS05850 (MKZ88_05850) | 1203162..1204049 | + | 888 | WP_020690740.1 | LysR family transcriptional regulator | - |
| MKZ88_RS05855 (MKZ88_05855) | 1204069..1205250 | + | 1182 | WP_038420464.1 | PLP-dependent aminotransferase family protein | - |
| MKZ88_RS05860 (MKZ88_05860) | 1205336..1205854 | + | 519 | WP_029883923.1 | hypothetical protein | - |
| MKZ88_RS05865 (MKZ88_05865) | 1205857..1206276 | - | 420 | WP_096897058.1 | nuclear transport factor 2 family protein | - |
| MKZ88_RS05870 (MKZ88_05870) | 1206375..1207106 | + | 732 | WP_038980944.1 | helix-turn-helix transcriptional regulator | - |
| MKZ88_RS05875 (MKZ88_05875) | 1207078..1207203 | - | 126 | Protein_1146 | nucleoside triphosphatase NudI | - |
| MKZ88_RS05880 (MKZ88_05880) | 1207253..1207600 | - | 348 | WP_038980942.1 | HigA family addiction module antitoxin | Antitoxin |
| MKZ88_RS05885 (MKZ88_05885) | 1207611..1207910 | - | 300 | WP_014832979.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MKZ88_RS05890 (MKZ88_05890) | 1208164..1208601 | - | 438 | WP_038980939.1 | hypothetical protein | - |
| MKZ88_RS05895 (MKZ88_05895) | 1208929..1210098 | - | 1170 | WP_096897060.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| MKZ88_RS05900 (MKZ88_05900) | 1210109..1212301 | - | 2193 | WP_045294745.1 | type I secretion system permease/ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11646.28 Da Isoelectric Point: 10.0182
>T236806 WP_014832979.1 NZ_CP092635:c1207910-1207611 [Enterobacter cloacae]
MINHFRDQWLEDFFLYGRSSNVIPSNLETVLARKLDLINAAISHRDLRSPPGNMFEALNPPLKGYSSIRVNRQYRLVFRW
AEGKADDLYLSPHKYTQHK
MINHFRDQWLEDFFLYGRSSNVIPSNLETVLARKLDLINAAISHRDLRSPPGNMFEALNPPLKGYSSIRVNRQYRLVFRW
AEGKADDLYLSPHKYTQHK
Download Length: 300 bp
>T236806 NZ_LR739069:3874868-3875446 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAGCGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAGCGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
Antitoxin
Download Length: 116 a.a. Molecular weight: 13018.00 Da Isoelectric Point: 7.0139
>AT236806 WP_038980942.1 NZ_CP092635:c1207600-1207253 [Enterobacter cloacae]
MILQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNARTQEELSRIKTVAEVIAKRKGGQPDVA
MILQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNARTQEELSRIKTVAEVIAKRKGGQPDVA
Download Length: 348 bp
>AT236806 NZ_LR739069:3874226-3874780 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|