Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4631390..4632144 | Replicon | chromosome |
| Accession | NZ_CP092627 | ||
| Organism | Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5I4V816 |
| Locus tag | MJ899_RS22565 | Protein ID | WP_017465947.1 |
| Coordinates | 4631390..4631701 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MJ899_RS22570 | Protein ID | WP_017465948.1 |
| Coordinates | 4631698..4632144 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MJ899_RS22535 (4627048) | 4627048..4627950 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| MJ899_RS22540 (4627947) | 4627947..4628582 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| MJ899_RS22545 (4628579) | 4628579..4629508 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| MJ899_RS22550 (4629555) | 4629555..4629845 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| MJ899_RS22555 (4629846) | 4629846..4630157 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| MJ899_RS22560 (4630375) | 4630375..4631304 | + | 930 | WP_001127708.1 | alpha/beta hydrolase | - |
| MJ899_RS22565 (4631390) | 4631390..4631701 | + | 312 | WP_017465947.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MJ899_RS22570 (4631698) | 4631698..4632144 | + | 447 | WP_017465948.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| MJ899_RS22575 (4632159) | 4632159..4633100 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| MJ899_RS22580 (4633145) | 4633145..4633582 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| MJ899_RS22585 (4633579) | 4633579..4634451 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| MJ899_RS22590 (4634445) | 4634445..4635044 | - | 600 | WP_001621364.1 | glucose-1-phosphatase | - |
| MJ899_RS22595 (4635235) | 4635235..4636038 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| MJ899_RS22600 (4636072) | 4636072..4636968 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12384.31 Da Isoelectric Point: 9.2528
>T236752 WP_017465947.1 NZ_CP092627:4631390-4631701 [Salmonella enterica subsp. enterica serovar Thompson]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T236752 NZ_LR735437:910839-911048 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16736.06 Da Isoelectric Point: 6.6451
>AT236752 WP_017465948.1 NZ_CP092627:4631698-4632144 [Salmonella enterica subsp. enterica serovar Thompson]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT236752 NZ_LR735437:910539-910832 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|