Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2567921..2568486 Replicon chromosome
Accession NC_012483
Organism Acidobacterium capsulatum ATCC 51196

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACP_RS17760 Protein ID WP_015897305.1
Coordinates 2568208..2568486 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ACP_RS10510 Protein ID WP_015897304.1
Coordinates 2567921..2568199 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACP_RS10485 2563020..2563907 - 888 WP_015897299.1 LysR family transcriptional regulator -
ACP_RS10490 2564051..2564869 + 819 WP_041839493.1 sugar phosphate isomerase/epimerase -
ACP_RS10495 2564882..2566240 + 1359 WP_015897301.1 asparagine--tRNA ligase -
ACP_RS10500 2566459..2567463 + 1005 WP_148215125.1 arginase -
ACP_RS10505 2567522..2567866 - 345 WP_015897303.1 hypothetical protein -
ACP_RS10510 2567921..2568199 - 279 WP_015897304.1 HigA family addiction module antidote protein Antitoxin
ACP_RS17760 2568208..2568486 - 279 WP_015897305.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACP_RS10515 2568555..2569757 + 1203 WP_015897306.1 D-alanine--D-alanine ligase -
ACP_RS10520 2569859..2570335 + 477 WP_015897307.1 hypothetical protein -
ACP_RS18110 2570342..2570569 - 228 WP_015897308.1 hypothetical protein -
ACP_RS10530 2570713..2571783 + 1071 WP_041839495.1 aspartyl protease family protein -
ACP_RS17405 2571775..2572449 - 675 WP_015897310.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10505.96 Da        Isoelectric Point: 9.8043

>T23673 WP_015897305.1 NC_012483:c2568486-2568208 [Acidobacterium capsulatum ATCC 51196]
MIRSFRHPGVERFFLTGSKAGIQPAHANKLRLQLAALHAATRPEDMCAPGWDLHPLKGNREGHWSVKVNGNWRLTFRFDG
PDAILVDYQDYH

Download         Length: 279 bp

>T23673 NC_012483:c2568486-2568208 [Acidobacterium capsulatum ATCC 51196]
ATGATTCGGTCTTTCAGGCACCCCGGCGTGGAAAGATTTTTCCTGACGGGATCAAAGGCGGGCATACAACCGGCACATGC
AAACAAGCTGCGACTTCAGCTTGCCGCCTTGCATGCGGCAACACGACCCGAGGATATGTGCGCCCCCGGCTGGGACTTGC
ACCCCCTCAAAGGAAATCGGGAAGGACACTGGTCAGTGAAGGTAAATGGGAACTGGCGCTTGACGTTTCGCTTCGATGGA
CCGGACGCGATACTGGTTGACTATCAGGATTATCATTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10139.72 Da        Isoelectric Point: 10.7431

>AT23673 WP_015897304.1 NC_012483:c2568199-2567921 [Acidobacterium capsulatum ATCC 51196]
MRMYNPPHPGEILAEYLNGRPVTATSTHLGVSRVALSRVLNGRAGISADMAIRLAEAFNTTPELWMNLQVQYDLARAGKA
RRKKITPLHDAA

Download         Length: 279 bp

>AT23673 NC_012483:c2568199-2567921 [Acidobacterium capsulatum ATCC 51196]
ATGCGAATGTATAACCCGCCTCACCCCGGCGAAATTTTAGCCGAATACTTGAATGGACGCCCGGTGACTGCGACCTCGAC
TCATCTGGGAGTTTCGCGTGTGGCTCTCTCGCGTGTATTGAACGGCAGGGCCGGCATCTCCGCGGACATGGCGATCCGCT
TGGCTGAAGCATTCAATACCACGCCCGAGCTATGGATGAACTTGCAGGTGCAGTACGACCTTGCGCGCGCTGGCAAAGCC
AGGAGAAAGAAGATCACGCCGCTGCATGATGCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References