Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 421131..421764 Replicon chromosome
Accession NZ_CP092588
Organism Vibrio gazogenes strain PB1

Toxin (Protein)


Gene name higB Uniprot ID A0A1M4TW45
Locus tag MKS89_RS17460 Protein ID WP_072954888.1
Coordinates 421131..421463 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1M4TVZ1
Locus tag MKS89_RS17465 Protein ID WP_072954890.1
Coordinates 421450..421764 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKS89_RS17440 (MKS89_17460) 417202..417957 - 756 WP_072954879.1 DUF3307 domain-containing protein -
MKS89_RS17445 (MKS89_17465) 417950..418600 - 651 WP_072954881.1 hypothetical protein -
MKS89_RS17450 (MKS89_17470) 418803..419489 - 687 WP_072954883.1 NYN domain-containing protein -
MKS89_RS17455 (MKS89_17475) 419892..420989 + 1098 WP_072954886.1 phosphotransferase -
MKS89_RS17460 (MKS89_17480) 421131..421463 + 333 WP_072954888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKS89_RS17465 (MKS89_17485) 421450..421764 + 315 WP_072954890.1 DNA-binding transcriptional regulator Antitoxin
MKS89_RS17470 (MKS89_17490) 421856..422752 - 897 WP_072954893.1 LysR family transcriptional regulator -
MKS89_RS17475 (MKS89_17495) 422857..423738 + 882 WP_072954895.1 N-carbamoylputrescine amidase -
MKS89_RS17480 (MKS89_17500) 423734..425134 + 1401 WP_072954898.1 APC family permease -
MKS89_RS17485 (MKS89_17505) 425131..426219 + 1089 WP_072954901.1 agmatine deiminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(44-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-101)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12951.77 Da        Isoelectric Point: 8.7159

>T236707 WP_072954888.1 NZ_CP092588:421131-421463 [Vibrio gazogenes]
MKSVFVESTIFEKYREDYLSDEEYRLFQVELMSNPKYGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYYLDEHHRFYLLT
IYAKNEMADLTADQKKQLKAFMEAWCNEQS

Download         Length: 333 bp

>T236707 NZ_LR699570:2202233-2202610 [Mycobacterium tuberculosis variant bovis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11764.28 Da        Isoelectric Point: 6.9907

>AT236707 WP_072954890.1 NZ_CP092588:421450-421764 [Vibrio gazogenes]
MSNRDLFGELSSALVEAKEHSEGKLTLKTHRVGDVGERHITPDEIVHIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRYPETLSQIAEL

Download         Length: 315 bp

>AT236707 NZ_LR699570:2202652-2203101 [Mycobacterium tuberculosis variant bovis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4TW45

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4TVZ1

References