Detailed information of TA system TA236701

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2441926..2442110
• Replicon: chromosome
• Accession: NZ_CP092581
• Organism: Staphylococcus aureus strain VRMSSA-WC111

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI52_RS12230
• Protein ID: WP_000482652.1
• Coordinates: 2442003..2442110 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2441926..2441986 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI52_RS12215 (MKI52_002418)	2437381..2437512	-	132	WP_223197975.1	hypothetical protein	-
MKI52_RS12220 (MKI52_002419)	2437779..2439512	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI52_RS12225 (MKI52_002420)	2439537..2441300	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2441926..2441986	+	61	-	-	Antitoxin
MKI52_RS12230 (MKI52_002421)	2442003..2442110	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI52_RS12235 (MKI52_002422)	2442244..2442630	-	387	WP_000779360.1	flippase GtxA	-
MKI52_RS12240 (MKI52_002423)	2442898..2444040	+	1143	WP_001176858.1	glycerate kinase	-
MKI52_RS12245 (MKI52_002424)	2444100..2444759	+	660	WP_000831298.1	membrane protein	-
MKI52_RS12250 (MKI52_002425)	2444941..2446152	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI52_RS12255 (MKI52_002426)	2446275..2446748	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236701 WP_000482652.1 NZ_CP092581:c2442110-2442003 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236701 NZ_LR699570:c1575776-1575375 [Mycobacterium tuberculosis variant bovis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236701 NZ_CP092581:2441926-2441986 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin