Detailed information of TA system TA236694

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1812101..1812281
• Replicon: chromosome
• Accession: NZ_CP092581
• Organism: Staphylococcus aureus strain VRMSSA-WC111

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI52_RS08640
• Protein ID: WP_001801861.1
• Coordinates: 1812101..1812196 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1812224..1812281 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI52_RS08610 (MKI52_001707)	1807264..1807914	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI52_RS08615 (MKI52_001708)	1807995..1808990	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI52_RS08620 (MKI52_001709)	1809065..1809691	+	627	WP_000669024.1	hypothetical protein	-
MKI52_RS08625 (MKI52_001710)	1809732..1810073	+	342	WP_000627540.1	DUF3969 family protein	-
MKI52_RS08630 (MKI52_001711)	1810174..1810746	+	573	WP_000414216.1	hypothetical protein	-
MKI52_RS08635 (MKI52_001712)	1810944..1811956	-	1013	Protein_1700	IS3 family transposase	-
MKI52_RS08640 (MKI52_001713)	1812101..1812196	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1812224..1812281	-	58	-	-	Antitoxin
MKI52_RS08645 (MKI52_001714)	1812319..1812420	+	102	WP_001792025.1	hypothetical protein	-
MKI52_RS08650 (MKI52_001715)	1812398..1812559	-	162	Protein_1703	transposase	-
MKI52_RS08655 (MKI52_001716)	1812544..1812954	-	411	WP_001808705.1	IS21 family transposase	-
MKI52_RS08660 (MKI52_001717)	1813495..1814723	-	1229	Protein_1705	restriction endonuclease subunit S	-
MKI52_RS08665 (MKI52_001718)	1814716..1816272	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI52_RS08670 (MKI52_001719)	1816436..1816570	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1806506..1858511	52005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236694 WP_001801861.1 NZ_CP092581:1812101-1812196 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236694 NZ_LR699570:1014556-1014990 [Mycobacterium tuberculosis variant bovis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236694 NZ_CP092581:c1812281-1812224 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin